20822-01-9

Basic information

• Product Name: Isoxazole, 3-(4-bromophenyl)-4,5-dihydro-5-phenyl-
• CAS NO: 20822-01-9
• Molecular Formula: C15H12BrNO
• Molecular Weight: 302.17
• Mol File: 20822-01-9.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Isoxazole, 3-(4-bromophenyl)-4,5-dihydro-5-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Isoxazole, 3-(4-bromophenyl)-4,5-dihydro-5-phenyl-(20822-01-9)
• EPA Substance Registry System: Isoxazole, 3-(4-bromophenyl)-4,5-dihydro-5-phenyl-(20822-01-9)

Safety Data

• Hazardous Substances Data: 20822-01-9(Hazardous Substances Data)

Upstream product

• 100-42-5 styrene 
• 25062-46-8 4-bromobenzaldehyde oxime 
• 1122-91-4 4-bromo-benzaldehyde 
• 176961-32-3 C₇H₅Br₂NO 
• 29203-58-5 4-bromo-N-hydroxybenzenecarboximidoyl chloride 
• 14525-88-3 1-(4-bromophenyl)-2-phenylcyclopropane 
• 2403-27-2 1-(4-bromophenyl)-3-phenyl-2-propen-1-one 
• 42811-75-6 p-bromobenzonitrile N-oxide 

Downstream Products

• 53573-21-0 3-(4-bromophenyl)-5-phenylisoxazole 

Relevant articles and documents

Simple preparation method of isoxazoline

The invention discloses a simple preparation method of isoxazoline. The simple preparation method is characterized in that a series of isoxazoline compounds are efficiently synthesized by using aldehyde, p-toluenesulfonhydrazide, olefin and tert-butyl nit

Synthesis of Isoxazolines and Isoxazoles via Metal-Free Desulfitative Cyclization

A novel, one-pot reaction for the synthesis of isoxazolines and isoxazoles is developed via a cascade process under metal-free conditions. The approach involves the formation of intramolecular C-N and C-O bonds and intermolecular C-C bonds from aromatic alkenes or alkynes and N -hydroxysulfonamides using hypervalent iodine(VII) and iodine as the oxidant. Activation of C-H and C-C bonds/construction of C-O bonds/elimination of SO 2 /C-N bond formation is achieved in sequence in the reaction system.

PhIO promoted synthesis of nitrile imines and nitrile oxides within a micellar core in aqueous media: A regiocontrolled approach to synthesizing densely functionalized pyrazole and isoxazoline derivatives

A highly efficient and general protocol has been developed for the facile synthesis of highly diversified 1,3,5-trisubstituted pyrazoles and 3,5-disubstituted 2-isoxazolines through one-pot tandem intermolecular, as well as intramolecular, dipolar [3 + 2] cycloaddition reactions. Chemoselective oxidation of aldohydrazone to nitrile imine and aldoximes to nitrile oxides by iodosobenzene in neutral aqueous media was performed. The scope of the reactions in regiocontrolled dipolar cycloaddition with olefins in the presence of PhIO toward highly substituted pyrazole and isoxazoline derivatives has been demonstrated. SDS converted the initially floating reaction mass and the organo-oxidant PhIO into a homogeneous mixture, which on stirring became a turbid emulsion. The micellar arrangement was confirmed by dynamic light scattering and optical microscopy. The new, green and metal free synthetic method enabled the execution of regiocontrolled tandem cycloaddition oxidation sequences leading to a library of pyrazole and isoxazoline derivatives.