208265-92-3

Basic information

• Product Name: Granulocyte colony-stimulating factor precursor
• Synonyms: Granulocyte colony-stimulating factor precursor;Neulasta;Pegfilgrastim;Colony-stimulating factor (human), 3-hydroxypropyl-N-methionyl-, 1-ether with alpha-methyl-omega-hydroxypoly(oxy-1,2-ethanediyl;Unii-3A58010674;pegfilgrastin
• CAS NO: 208265-92-3
• Molecular Formula: C18H24FN3O6S
• Molecular Weight: 429.4630632
• Product Categories: Intermediates & Fine Chemicals;Peptides;Pharmaceuticals
• Mol File: 208265-92-3.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Granulocyte colony-stimulating factor precursor(CAS DataBase Reference)
• NIST Chemistry Reference: Granulocyte colony-stimulating factor precursor(208265-92-3)
• EPA Substance Registry System: Granulocyte colony-stimulating factor precursor(208265-92-3)

Safety Data

• Hazardous Substances Data: 208265-92-3(Hazardous Substances Data)

Usage

Description

Granulocyte colony-stimulating factor precursor, also known as G-CSF precursor, is a naturally occurring protein that plays a crucial role in the regulation of neutrophil production. It is involved in the stimulation of the bone marrow to produce granulocytes, a type of white blood cell essential for the immune system. The G-CSF precursor is particularly important in the context of medical treatments that may deplete the body's white blood cell count, such as chemotherapy.

Uses

Used in Medical Applications:
Granulocyte colony-stimulating factor precursor is used as an immunostimulator for patients undergoing strong chemotherapy. It helps in the rapid recovery of neutrophil counts, reducing the risk of infection and improving the overall immune response.
Used in Oncology:
In the field of oncology, G-CSF precursor is used as an immunostimulator to support patients undergoing aggressive chemotherapy treatments. It aids in the mobilization of hematopoietic stem cells, which are crucial for the regeneration of the immune system after chemotherapy-induced myelosuppression.
Used in Hematopoietic Stem Cell Transplantation:
Granulocyte colony-stimulating factor precursor is also used in the context of hematopoietic stem cell transplantation. It facilitates the mobilization and collection of stem cells from the donor, which are then transplanted into the recipient to restore the immune system and blood-forming capabilities.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, G-CSF precursor is utilized in the development of immunostimulatory drugs, such as Pegfilgrastim. These drugs are designed to mimic the effects of the natural G-CSF precursor, providing support to patients undergoing strong chemotherapy and those in need of immune system enhancement.

Clinical Use

Pegylated recombinant human granulocyte-colony stimulating factor (rhG-CSF): Reduction of duration of neutropenia (except in chronic myeloid leukaemia and myelodysplastic syndromes)

Drug interactions

Potentially hazardous interactions with other drugs Cytotoxics: neutropenia possibly exacerbated if administered with capecitabine, fluorouracil and tegafur.

Metabolism

Eliminated by neutrophil-mediated clearance.