20845-34-5

Basic information

• Product Name: 1-Methyl-2-piperidinemethanol
• Synonyms: 1-METHYL-2-PIPERIDINEMETHANOL;1-METHYLPIPERIDINE-2-METHANOL;2-HYDROXYMETHYL-N-METHYLPIPERIDINE;2-HYDROXYMETHYL-1-METHYLPIPERIDINE;(1-Methyl-2-piperidinyl)methanol;1-Methyl-2-hydroxymethylpiperidine;2-Piperidinemethanol, 1-methyl-;N-Methylpiperidine-2-carbinol
• CAS NO: 20845-34-5
• Molecular Formula: C₇H₁₅NO
• Molecular Weight: 129.2
• EINECS: 244-078-6
• Product Categories: Piperidine;Building Blocks;Heterocyclic Building Blocks;Piperidines
• Mol File: 20845-34-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 79-80 °C7 mm Hg(lit.)
• Flash Point: 178 °F
• Appearance: Clear brown/Liquid
• Density: 0.984 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.159mmHg at 25°C
• Refractive Index: n20/D 1.4823(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Dichloromethane, Methanol
• PKA: 15.08±0.10(Predicted)
• BRN: 103612
• CAS DataBase Reference: 1-Methyl-2-piperidinemethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-2-piperidinemethanol(20845-34-5)
• EPA Substance Registry System: 1-Methyl-2-piperidinemethanol(20845-34-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 20845-34-5(Hazardous Substances Data)

Usage

Description

1-Methyl-2-piperidinemethanol is an organic compound with the chemical structure featuring a piperidine ring, a methyl group, and a hydroxyl group. It is a clear brown liquid and has been studied for its standard molar energy of combustion.

Uses

Used in Pharmaceutical Industry:
1-Methyl-2-piperidinemethanol is used as an intermediate in the synthesis of various pharmaceutical compounds, specifically for the preparation of substances that are beneficial in the treatment of dermatological conditions and for skin protection.
Used in Chemical Research:
1-Methyl-2-piperidinemethanol is used as a reagent in the synthesis of phenylpyridone derivatives, which have been found to act as anti-obesity agents in mice, contributing to the development of potential treatments for obesity-related conditions.
Used in Chemical Synthesis:
1-Methyl-2-piperidinemethanol serves as a key component in the synthesis of various chemical compounds, particularly in the pharmaceutical and chemical industries, due to its unique chemical structure and properties.

InChI:InChI=1/C7H15NO/c1-8-5-3-2-4-7(8)6-9/h7,9H,2-6H2,1H3/p+1/t7-/m1/s1

Upstream product

• 116570-78-6 2-hydroxymethyl-1-methyl-pyridinium; bromide 
• 34285-36-4 1-methyl-2-ethoxycarbonylpyridinium iodide 
• 98303-20-9 1-(tert-butoxycarbonyl)piperidine-2-carboxylic acid 
• 1690-74-0 methyl 1-methyl-2-piperidinecarboxylate 
• 7730-87-2 1-methylpiperidine-2-carboxylic acid 
• 67-56-1 methanol 
• 3433-37-2 piperidin-2-ylmethanol 
• 4043-87-2 pipecolic Acid 
• 586-98-1 2-Hydroxymethylpyridine 
• 56-81-5 glycerol 

Downstream Products

• 931-20-4 1-methylpiperidin-2-one 
• 41467-01-0 N-methylpiperidine-2-carboxaldehyde 
• 49665-74-9 2-(chloromethyl)-N-methyl-piperidine 
• 622369-26-0 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[(1-methylpiperidine-2-yl)methoxy]quinoline-3-carbonitrile 
• 27483-92-7 1-methylpiperidin-2-ylmethyl chloride hydrochloride 
• 868542-05-6 (2-iodo-phenyl)-[2-methyl-1-(1-methyl-piperidin-2-ylmethyl)-1H-indol-3-yl]-methanone 

Relevant articles and documents

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AMINOESTER DERIVATIVES

The invention relates to novel compounds which are both phosphodiesterase 4 (PDE4) enzymeinhibitorsand muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof.

Catalytic conversion of glycerol to allyl alcohol; Effect of a sacrificial reductant on the product yield

A continuous process for the conversion of glycerol to allyl alcohol, where ammonia or organic acids are added to the feed as sacrificial reductants, was investigated. Significant enhancement on the rate of formation and yield of the allyl alcohol is observed with some of the reducing agents examined over an alumina-supported iron catalyst. Optimising the molar ratio of the reductant relative to feed glycerol results in an increase in the yield of allyl alcohol from 9% (in the absence of additives) to 11.3% with ammonia, 15.1% with ammonium hydroxide, 17.8% with oxalic acid and 19.5% with formic acid. Moreover, the addition of other organic acids, which are produced in a typical glycerol conversion experiment, was studied. However, acetic and propanoic acids had little effect on the rate of formation of allyl alcohol. Analysis of the product distribution in the liquid and gas phases when oxalic and formic acids were added suggests a two-step process for the formation of allyl alcohol under the operating conditions of the reaction; the initial step involves the dehydration of glycerol while the second comprises the reduction of the species produced in step one. the Partner Organisations 2014.