208512-39-4

Basic information

• Product Name: 3-(4-carboxymethylsulfanyl-2,5-dichloro-phenyl)-acrylic acid tert-butyl ester
• Synonyms: 3-(4-carboxymethylsulfanyl-2,5-dichloro-phenyl)-acrylic acid tert-butyl ester
• CAS NO: 208512-39-4
• Molecular Weight: 363.262
• Mol File: 208512-39-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(4-carboxymethylsulfanyl-2,5-dichloro-phenyl)-acrylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-carboxymethylsulfanyl-2,5-dichloro-phenyl)-acrylic acid tert-butyl ester(208512-39-4)
• EPA Substance Registry System: 3-(4-carboxymethylsulfanyl-2,5-dichloro-phenyl)-acrylic acid tert-butyl ester(208512-39-4)

Safety Data

• Hazardous Substances Data: 208512-39-4(Hazardous Substances Data)

Upstream product

• 208512-43-0 3-(2,5-dichloro-4-methoxycarbonylmethylsulfanyl-phenyl)-acrylic acid tert-butyl ester 
• 1663-39-4 tert-Butyl acrylate 
• 583-78-8 2,5-dichlorophenol 
• 7587-15-7 2,3-dichloro-4-iodophenol 
• 7145-82-6 2,4,5-trichloroiodobenzene 
• 208512-76-9 2,3-dichloro-4-iodothiophenol 
• 208512-77-0 (2,5-dichloro-4-iodo-phenylsulfanyl)-acetic acid methyl ester 
• 208512-75-8 dimethyl-thiocarbamic acid S-(2,5-dichloro-4-iodo-phenyl) ester 
• 208512-51-0 3-(2,4,5-trichloro-phenyl)-acrylic acid tert-butyl ester 

Downstream Products

• 208512-83-8 (6R,7R)-7-{2-[4-((E)-2-Carboxy-vinyl)-2,5-dichloro-phenylsulfanyl]-acetylamino}-3-chloromethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 208512-82-7 (6R,7R)-7-{2-[4-((E)-2-tert-Butoxycarbonyl-vinyl)-2,5-dichloro-phenylsulfanyl]-acetylamino}-3-chloromethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 

Relevant articles and documents

Anti-MRSA cephems. Part 2: C-7 cinnamic acid derivatives

Forty-five novel cephalosporin derivatives with activity against methicillin-resistant Staphylococcus aureus (MRSA) are described. The compounds contain novel cinnamic acid moieties at C-7 that were synthesized using a key Heck reaction followed by nucleophilic aromatic substitution reactions. The most active compound (41) displayed an MIC90 against MRSA of 1.0 μg/mL, and a PD50 of 0.8 mg/kg. Compound 14 was found to be very safe in a mouse model of acute toxicity.