208512-58-7

Basic information

• Product Name: (2,5-dichloro-4-methoxycarbonylmethylsulfanyl-benzoylamino)-acetic acid tert-butyl ester
• Synonyms: (2,5-dichloro-4-methoxycarbonylmethylsulfanyl-benzoylamino)-acetic acid tert-butyl ester
• CAS NO: 208512-58-7
• Molecular Weight: 408.303
• Mol File: 208512-58-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2,5-dichloro-4-methoxycarbonylmethylsulfanyl-benzoylamino)-acetic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2,5-dichloro-4-methoxycarbonylmethylsulfanyl-benzoylamino)-acetic acid tert-butyl ester(208512-58-7)
• EPA Substance Registry System: (2,5-dichloro-4-methoxycarbonylmethylsulfanyl-benzoylamino)-acetic acid tert-butyl ester(208512-58-7)

Safety Data

• Hazardous Substances Data: 208512-58-7(Hazardous Substances Data)

Upstream product

• 208512-54-3 2,5-dichloro-4-methoxycarbonylmethylsulfanyl-benzoic acid tert-butyl ester 
• 208512-51-0 3-(2,4,5-trichloro-phenyl)-acrylic acid tert-butyl ester 
• 208512-53-2 2,4,5-trichloro-benzoic acid tert-butyl ester 
• 50-82-8 2,4,5-trichlorobenzoic acid 
• 35696-87-8 2,4,5-trichlorobenzaldehyde 
• 6456-74-2 Glycine tert-butyl ester 
• 208512-56-5 2,5-dichloro-4-methoxycarbonylmethylsulfanyl-benzoic acid 

Relevant articles and documents

Anti-MRSA cephems. Part 3: additional C-7 acid derivatives.

Twenty-seven novel cephalosporin derivatives with activity against methicillin-resistant Staphylococcus aureus (MRSA) are described. The compounds contain novel acid moieties at C-7 that were synthesized using nucleophilic aromatic substitution reactions and Stille couplings. The most interesting compound (6) displayed an MIC(90) against MRSA of 3.7 microg/mL, and an average PD(50) of 3.9 mg/kg.