20862-83-3 Usage
Description
2-(2-piperidyl)-1H-indole, with the CAS number 20862-83-3, is an organic compound belonging to the indole class. It features a piperidine ring fused to the indole structure, which contributes to its unique chemical and biological properties. 2-(2-piperidyl)-1H-indole has garnered interest in the pharmaceutical and chemical industries due to its potential applications in various therapeutic areas.
Uses
Used in Cancer Research:
2-(2-piperidyl)-1H-indole is used as a research tool for elucidating the binding modes of inhibitors to the RAS isoforms, which are crucial proteins in human cancers. By understanding these interactions, scientists can develop more effective drugs targeting RAS proteins, leading to improved treatment options for various types of cancer.
Used in Proliferative and Inflammatory Disease Treatment:
In the pharmaceutical industry, 2-(2-piperidyl)-1H-indole is utilized as a lysophosphatidic acid (LPA) receptor antagonist. LPA receptors play a significant role in the regulation of cell proliferation and inflammation. By acting as an antagonist, this compound can help in the treatment of proliferative and inflammatory diseases by modulating the activity of these receptors and reducing the associated pathological effects.
Check Digit Verification of cas no
The CAS Registry Mumber 20862-83-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,8,6 and 2 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 20862-83:
(7*2)+(6*0)+(5*8)+(4*6)+(3*2)+(2*8)+(1*3)=103
103 % 10 = 3
So 20862-83-3 is a valid CAS Registry Number.
InChI:InChI=1/C13H16N2/c1-2-6-11-10(5-1)9-13(15-11)12-7-3-4-8-14-12/h1-2,5-6,9,12,14-15H,3-4,7-8H2
20862-83-3Relevant articles and documents
Design and synthesis of indolo[2,3-a]quinolizin-7-one inhibitors of the ZipA-FtsZ interaction
Jennings, Lee D.,Foreman, Ken W.,Rush III, Thomas S.,Tsao, Desiree H. H.,Mosyak, Lidia,Li, Yuanhong,Sukhdeo, Mohani N.,Ding, Weidong,Dushin, Elizabeth G.,Kenny, Cynthia Hess,Moghazeh, Soraya L.,Petersen, Peter J.,Ruzin, Alexey V.,Tuckman, Margareta,Sutherland, Alan G.
, p. 1427 - 1431 (2004)
The binding of FtsZ to ZipA is a potential target for antibacterial therapy. Based on a small molecule inhibitor of the ZipA-FtsZ interaction, a parallel synthesis of small molecules was initiated which targeted a key region of ZipA involved in FtsZ bindi
Synthesis of 7-Oxo-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine
Tompkins, David C.,Nelson, Randall B.,Dolby, Lloyd J.,Gribble, Gordon W.
, p. 2168 - 2171 (2018)
A short synthesis of 7-oxo-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine from 2-acetylpyridine and phenylhydrazine is described. Ring C is forged using 2-chloro-N,N-dimethylacetamide. This derivative of the natural alkaloid 1,2,3,4,6,7,12,12b-octah
Benzyl Piperidine Compounds as Lysophosphatidic Acid (LPA) Receptor Antagonist
-
, (2015/02/18)
The invention provides novel substituted benzyl piperidine compounds according to Formula (I) as lysophosphatidic acid (LPA) receptor antagonists, their manufacture and use for the treatment of proliferative or inflammatory diseases, such as cancer, fibrosis or arthritis.
