208655-00-9Relevant articles and documents
An efficient one-pot construction of substituted pyrimidinones
Lu, Yuelie,Xiang, Tingjian,Bartberger, Michael D.,Bernard, Charles,Bostick, Tracy,Huang, Liang,Liu, Longbin,Siegmund, Aaron,Sukay, Gregory,Guo, Gary,Elipe, Maria Silva,Tormos, Wanda,Dominguez, Celia,Koch, Kevin,Burgess, Laurence E.,Basil, Thomas C.,Ibrahim, Prabha,Hummel, Conrad
, p. 11714 - 11723 (2007/10/03)
A concise, scaleable synthesis of building block 10 for p38 kinase inhibitor B is described. The key step is the one-pot construction of 5-aryl-3-methyl-2-methylsulfanyl-6-pyridin-4-yl-3H-pyrimidin-4-one 4 from arylacetic acid ethyl ester 1. Subsequent hy
Carbon-carbon bond construction at the 2-position of polysubstituted pyrimidinones
Zhang, Dawei,Sham, Kelvin,Cao, Guo-Qiang,Hungate, Randall,Dominguez, Celia
, p. 8901 - 8903 (2007/10/03)
A novel synthetic method to introduce a carbon-carbon bond at the 2-position of pyrimidinones via nucleophilic addition of Grignard reagents to 2-cyano pyrimidinones at ambient conditions is disclosed. This unique approach leads to the preparation of such