208655-26-9

Basic information

• Product Name: 4(3H)-Pyrimidinone, 3-methyl-5-(3-methylphenyl)-2-(methylthio)-6-(4-pyridinyl)-
• CAS NO: 208655-26-9
• Molecular Formula: C18H17N3OS
• Molecular Weight: 323.418
• Mol File: 208655-26-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4(3H)-Pyrimidinone, 3-methyl-5-(3-methylphenyl)-2-(methylthio)-6-(4-pyridinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(3H)-Pyrimidinone, 3-methyl-5-(3-methylphenyl)-2-(methylthio)-6-(4-pyridinyl)-(208655-26-9)
• EPA Substance Registry System: 4(3H)-Pyrimidinone, 3-methyl-5-(3-methylphenyl)-2-(methylthio)-6-(4-pyridinyl)-(208655-26-9)

Safety Data

• Hazardous Substances Data: 208655-26-9(Hazardous Substances Data)

Upstream product

• 100-48-1 pyridine-4-carbonitrile 
• 7476-80-4 m-tolyl butyrate 
• 556-61-6 methyl thioisocyanate 
• 74-88-4 methyl iodide 
• 40061-55-0 ethyl m-methylphenylacetate 

Downstream Products

• 208655-25-8 2-Chloro-3-methyl-6-(pyridin-4-yl)-5-(3-methylphenyl)-4(3H)-pyrimidinone 
• 208655-24-7 2-hydroxy-3-methyl-6-pyridin-4-yl-5-m-tolyl-3H-pyrimidin-4-one 

Relevant articles and documents

An efficient one-pot construction of substituted pyrimidinones

A concise, scaleable synthesis of building block 10 for p38 kinase inhibitor B is described. The key step is the one-pot construction of 5-aryl-3-methyl-2-methylsulfanyl-6-pyridin-4-yl-3H-pyrimidin-4-one 4 from arylacetic acid ethyl ester 1. Subsequent hy

Substituted pyrimidinone and pyridone compounds and methods of use

Selected novel substituted pyrimidinone and pyridone compounds are effective for prophylaxis and treatment of diseases, such as TNF- alpha , IL-1 beta , IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving inflammation, pain, diabetes and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.