208655-63-4Relevant articles and documents
Synthesis of 5S-(1-oxoalkyl and aryl)2-pyrrolidinone derivatives
Deskus, Jeffrey,Fan, Dongping,Smith, Michael B.
, p. 1649 - 1659 (1998)
N-Benzyl pyroglutamate esters react with aryllithium reagents and methyllithium to give moderate to good yields of 5-(I-oxoaryl) or 5-(I- oxoalkyl)-2-pyrrolidinone derivatives. The reaction proceeds without racemization, but is accompanied by formation of 5-(I-hydroxy- l-alkyl)-2- pyrrolidinone derivatives. This reaction gives very poor yields of ketone products with most other alkyl organolithium reagents such as n-butyllithium. Grignard reagents react to give primarily the alcohol.