209-81-4Relevant articles and documents
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Jessep,Leaver
, p. 790 (1970)
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Synthesis of Cyclazine and Benzocyclazine Derivatives by Use of the Cycloaddition Reaction of Indolizines and Dimethyl Acetylenedicarboxylate
Tominaga, Yoshinori,Shiroshita, Yoshihide,Kurokawa, Tomohiko,Gotou, Hiromi,Matsuda, Yoshiro,Hosomi, Akira
, p. 477 - 487 (2007/10/02)
The reaction of 1-ethoxycarbonylmethylpyridinium bromides 5a-k with nitro ketene dithioacetal, 1,1-bis(methylthio)-2-nitroethylene (2), in the presence of triethylamine in ethanol gave the desired ethyl 2-methylthioindolizine-3-carboxylates 3a-k in good y
An Improved Synthesis of Cyclazines from 3H-Pyrrolizines
Batroff, Volker,Flitsch, Wilhelm,Leaver, Derek,Skinner, David
, p. 1649 - 1658 (2007/10/02)
The reaction of 3H-pyrrolizines 3 with vinamidinium salts 4 provides a new and generally applicable route to cyclazines 5.Pyrrolizinefulvenes are intermediates of this reaction as shown using 3f as an example. - Cyclopentacyclazines 11 were prepared from the hitherto unknown 3H-pyrrolizines 3b, c, d and the pyrrolizine esters 3e, f with the cyclopentadiene iminium salt 10 under conditions which have been described previously.Additional evidence for a close similarity between cyclazines 11 and the corresponding azulenes has been obtained from the UV spectra of 11.