2092153-80-3

Basic information

• Product Name: 4-bromopyrazolo[1,5-a]pyridine-3-carbonitrile
• CAS NO: 2092153-80-3
• Molecular Weight: 222.044
• Mol File: 2092153-80-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-bromopyrazolo[1,5-a]pyridine-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromopyrazolo[1,5-a]pyridine-3-carbonitrile(2092153-80-3)
• EPA Substance Registry System: 4-bromopyrazolo[1,5-a]pyridine-3-carbonitrile(2092153-80-3)

Safety Data

• Hazardous Substances Data: 2092153-80-3(Hazardous Substances Data)

Upstream product

• 55899-13-3 1-amino-3-bromopyridin-1-ium 2,4,6-trimethylbenzenesulfonate 
• 107-13-1 acrylonitrile 

Relevant articles and documents

Regioselective Synthesis of Pyrazolo[1,5- a]pyridine via TEMPO-Mediated [3 + 2] Annulation-Aromatization of N-Aminopyridines and α,β-Unsaturated Compounds

A TEMPO-mediated [3 + 2] annulation-aromatization protocol for the preparation of pyrazolo[1,5-a]pyridines from N-aminopyridines and α,β-unsaturated compounds was developed. The procedure offered multisubstituted pyrazolo[1,5-a]pyridines in good to excellent yield with high and predictable regioselectivity. The modification of marketed drugs including Loratadine, Abiraterone, and Metochalcone, and a one-pot three-step gram scale synthesis of key intermediate for the preparation of Selpercatinib were demonstrated. Mechanism studies show that TEMPO serves both as a Lewis acid and as an oxidant.