20932-04-1

Basic information

• Product Name: 2-(4-CHLOROPHENYL)-3,5-DIOXO-2,3,4,5-TETRAHYDRO-1,2,4-TRIAZINE-6-CARBONITRILE
• Synonyms: 2-(4-CHLOROPHENYL)-3,5-DIOXO-2,3,4,5-TETRAHYDRO-1,2,4-TRIAZINE-6-CARBONITRILE
• CAS NO: 20932-04-1
• Molecular Formula: C₁₀H₅ClN₄O₂
• Molecular Weight: 248.63
• Mol File: 20932-04-1.mol
• Article Data: 2

Chemical Properties

• Melting Point: 220-224°C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.57g/cm³
• Refractive Index: 1.714
• CAS DataBase Reference: 2-(4-CHLOROPHENYL)-3,5-DIOXO-2,3,4,5-TETRAHYDRO-1,2,4-TRIAZINE-6-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-CHLOROPHENYL)-3,5-DIOXO-2,3,4,5-TETRAHYDRO-1,2,4-TRIAZINE-6-CARBONITRILE(20932-04-1)
• EPA Substance Registry System: 2-(4-CHLOROPHENYL)-3,5-DIOXO-2,3,4,5-TETRAHYDRO-1,2,4-TRIAZINE-6-CARBONITRILE(20932-04-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 20932-04-1(Hazardous Substances Data)

Usage

General Description

2-(4-Chlorophenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile is a complex chemical compound. It belongs to the family of triazine, characterized by a ring-like atom structure composed of three nitrogen atoms and three carbon atoms. The specific structure of this compound includes additional functional groups, such as a chlorophenyl group and a carbonitrile group, which add to its unique properties. Therefore, its physical and chemical characteristics, including reactivity, polarity, and solubility, will depend on these functional groups and the way they interact with each other. This chemical could be involved in various applications, depending on its properties, but specific use cases or potential applications cannot be provided without further information.

InChI:InChI=1/C10H5ClN4O2/c11-6-1-3-7(4-2-6)15-10(17)13-9(16)8(5-12)14-15/h1-4H,(H,13,16,17)

Upstream product

• 123822-72-0 ethyl (Z)-(2-cyano-2-(2-(4-chlorophenyl)hydrazono)-2-cyanoacetyl)carbamate 
• 106-47-8 4-chloro-aniline 
• 30615-97-5 N-<(4-Chlor-phenyl-hydrazono)-cyan-acetyl>-carbamidsaeure-ethylester 

Downstream Products

• 54994-97-7 2-(4-chlorophenyl)-4-methyl-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile 

Relevant articles and documents

Design, synthesis and biological evaluation of novel N-[4-(2-fluorophenoxy)pyridin-2-yl]cyclopropanecarboxamide derivatives as potential c-Met kinase inhibitors

Three series of novel 4-phenoxypyridine derivatives containing 4-methyl-6-oxo-1,6-dihydropyridazine- 3-carboxamide, 5-methyl-4-oxo-1,4-dihydropyridazine-3-carboxamide and 4-methyl-3,5-dioxo-2,3,4,5- tetrahydro-1,2,4-triazine-6-carboxamide moieties were synthesized and evaluated for their in vitro inhibitory activitives against c-Met kinase and cytotoxic activitives against A549, H460, HT-29 cancer cell lines. The results indicated that most of the compounds showed moderate to good antitumor activitives. The most promising compound 26a (with c-Met IC50 value of 0.016 μM) showed remarkable cytotoxicity against A549, H460, and HT-29 cell lines with IC50 values of 1.59 μM, 0.72 μM and 0.56 μM, respectively. Their preliminary structure-activity relationships (SARs) studies indicate that 4-methyl-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carboxamide was more preferred as linker part, and electron-withdrawing groups on the terminal phenyl rings are beneficial for improving the antitumor activitives. Furthermore, the colony formation, acridine orange/ethidium bromide (AO/EB) staining, apoptosis, and wound-healing assay of 26a were performed on HT-29 and/or A549 cell lines.