209412-06-6

Basic information

• Product Name: 2-(6-CHLORO-3-PYRIDAZINYL)-2-(2,6-DICHLOROPHENYL)ACETONITRILE
• Synonyms: AKOS 90877;2-(6-CHLORO-3-PYRIDAZINYL)-2-(2,6-DICHLOROPHENYL)ACETONITRILE;2-(6-CHLOROPYRIDAZIN-3-YL)-2-(2,6-DICHLOROPHENYL)ACETONITRILE;3-PYRIDAZINEACETONITRILE, 6-CHLORO-A-(2,6-DICHLOROPHENYL)-;2-(2,6-dichlorophenyl)-2-(6-chloropyridazin-3-yl)acetonitrile
• CAS NO: 209412-06-6
• Molecular Formula: C₁₂H₆Cl₃N₃
• Molecular Weight: 298.56
• Mol File: 209412-06-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 142-144°C
• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(6-CHLORO-3-PYRIDAZINYL)-2-(2,6-DICHLOROPHENYL)ACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(6-CHLORO-3-PYRIDAZINYL)-2-(2,6-DICHLOROPHENYL)ACETONITRILE(209412-06-6)
• EPA Substance Registry System: 2-(6-CHLORO-3-PYRIDAZINYL)-2-(2,6-DICHLOROPHENYL)ACETONITRILE(209412-06-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 209412-06-6(Hazardous Substances Data)

Usage

General Description

2-(6-Chloro-3-pyridazinyl)-2-(2,6-dichlorophenyl)acetonitrile is a chemical compound with a molecular formula C16H8Cl3N3. It is a nitrile derivative, containing both pyridazine and phenyl rings that are substituted with chloro groups. 2-(6-CHLORO-3-PYRIDAZINYL)-2-(2,6-DICHLOROPHENYL)ACETONITRILE is commonly used in the field of pharmaceuticals and agrochemicals due to its potential biological activities. It has been investigated for its potential as an insecticide and herbicide, as well as for its role in developing new drugs for various medical conditions. Its precise mechanism of action and specific applications continue to be the subject of ongoing research and study.

Upstream product

• 141-30-0 3,6-dichlorpyridazine 
• 3215-64-3 2,6-dichlorophenylacetonitrile 

Downstream Products

• 209412-07-7 α-(2,6-dichlorophenyl)-6-(phenylthio)pyridazine-3-acetonitrile 
• 209412-22-6 α-(2,6-dichlorophenyl)-α-[6-(2,4-difluorophenylthio)-3-pyridazinyl]acetonitrile 
• 209412-23-7 C₁₈H₁₁N₃SF₂OCl₂ 
• 209412-08-8 α-(2,6-dichlorophenyl)-6-(phenylthio)pyridazine-3-acetamide 
• 209409-98-3 5-(2,6-dichlorophenyl)-2-(phenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one 
• 1240424-01-4 N-[2-({6-[cyano(2,6-dichlorophenyl)methyl]pyridazin-3-yl}sulfanyl)benzyl]-3-fluoro-5-(morpholin-4-yl)benzamide 
• 1326560-57-9 2-(2,6-dichlorophenyl)-2-(6-((4-fluorophenyl)thio)pyridazin-3-yl)acetonitrile 
• 209410-04-8 5-(2,6-dichlorophenyl)-2-(4-fluorophenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one 
• 1326560-59-1 2-(2,6-dichlorophenyl)-2-(6-((4-fluorophenyl)thio)pyridazin-3-yl)acetamide 

Relevant articles and documents

Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells

The p38 mitogen-activated protein kinase inhibitor VX-745 is prepared rapidly and efficiently in a four-step sequence using a combination of conductive heating and microwave-mediated steps. Its inhibitory activity was confirmed in hTERT immortalized HCA2

The discovery of VX-745: A novel and selective p38α kinase inhibitor

The synthesis of novel, selective, orally active 2,5-disubstituted 6H-pyrimido[1,6-b]pyridazin-6-one p38α inhibitors is described. Application of structural information from enzyme-ligand complexes guided the selection of screening compounds, leading to t

An improved synthesis of 5-(2,6-dichlorophenyl)-2-(phenylthio)-6H- pyrimido[1,6-b]pyridazin-6-one (a VX-745 analog)

An improved procedure for the synthesis an analog of the p38 inhibitor compound VX-745 is reported.