209482-01-9

Basic information

• Product Name: 1-(2-methoxy-4-nitrophenyl)-4-methylpiperazine
• Synonyms: 1-(2-methoxy-4-nitrophenyl)-4-methylpiperazine
• CAS NO: 209482-01-9
• Molecular Formula: C₁₂H₁₇N₃O₃
• Molecular Weight: 251.28168
• EINECS: -0
• Mol File: 209482-01-9.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 409.7±45.0 °C(Predicted)
• Appearance: /
• Density: 1.204±0.06 g/cm3(Predicted)
• PKA: 7.27±0.42(Predicted)
• CAS DataBase Reference: 1-(2-methoxy-4-nitrophenyl)-4-methylpiperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-methoxy-4-nitrophenyl)-4-methylpiperazine(209482-01-9)
• EPA Substance Registry System: 1-(2-methoxy-4-nitrophenyl)-4-methylpiperazine(209482-01-9)

Safety Data

• Hazardous Substances Data: 209482-01-9(Hazardous Substances Data)

Usage

Description

1-(2-methoxy-4-nitrophenyl)-4-methylpiperazine is a chemical compound belonging to the class of piperazine derivatives. It is a yellow solid with a molecular formula of C12H18N4O3 and a molecular weight of 258.3 g/mol, featuring a piperazine ring with a 2-methoxy-4-nitrophenyl group and a methyl group attached to it. 1-(2-methoxy-4-nitrophenyl)-4-methylpiperazine is commonly used in pharmacological research and drug development, making it a promising target for medicinal chemistry studies due to its unique chemical structure.

Uses

Used in Pharmaceutical Research:
1-(2-methoxy-4-nitrophenyl)-4-methylpiperazine is used as a research compound for the development of new drugs targeting various diseases and conditions. Its unique chemical structure allows for the exploration of its potential therapeutic effects and mechanisms of action.
Used in Medicinal Chemistry Studies:
In the field of medicinal chemistry, 1-(2-methoxy-4-nitrophenyl)-4-methylpiperazine is used as a starting material or a structural motif for the design and synthesis of novel compounds with potential therapeutic applications. Its chemical properties and structural features make it an attractive candidate for further modification and optimization to enhance its pharmacological properties.
Used in Drug Delivery Systems:
1-(2-methoxy-4-nitrophenyl)-4-methylpiperazine may also be employed in the development of drug delivery systems, where its chemical properties can be utilized to improve the bioavailability, targeting, and overall efficacy of therapeutic agents. This application can be particularly useful in the context of targeted drug delivery, where the compound's structural features can be exploited to enhance the selectivity and specificity of drug action.

Upstream product

• 109-01-3 1-methyl-piperazine 
• 1009-36-5 2-chloro-5-nitroanisole 
• 77337-82-7 1-bromo-2-methoxy-4-nitrobenzene 
• 7787-70-4 copper(I) bromide 
• 454-16-0 1-fluoro-2-methoxy-4-nitrobenzene 

Downstream Products

• 156428-85-2 3-methoxy-4-(4-methylpiperazin-1-yl)aniline 
• 1404437-49-5 N-(3-methoxy-4-(4-methylpiperazin-1-yl)phenyl)-1-(4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine 

Relevant articles and documents

Discovery of a Pyrimidothiazolodiazepinone as a Potent and Selective Focal Adhesion Kinase (FAK) Inhibitor

Focal adhesion kinase (FAK) is a tyrosine kinase with prominent roles in protein scaffolding, migration, angiogenesis, and anchorage-independent cell survival and is an attractive target for the development of cancer therapeutics. However, current FAK inhibitors display dual kinase inhibition and/or significant activity on several kinases. Although multitargeted activity is at times therapeutically advantageous, such behavior can also lead to toxicity and confound chemical-biology studies. We report a novel series of small molecules based on a tricyclic pyrimidothiazolodiazepinone core that displays both high potency and selectivity for FAK. Structure-activity relationship (SAR) studies explored modifications to the thiazole, diazepinone, and aniline "tail,"which identified lead compound BJG-03-025. BJG-03-025 displays potent biochemical FAK inhibition (IC50 = 20 nM), excellent kinome selectivity, activity in 3D-culture breast and gastric cancer models, and favorable pharmacokinetic properties in mice. BJG-03-025 is a valuable chemical probe for evaluation of FAK-dependent biology.

COMPOUNDS AND THEIR USES AS SPLEEN TYROSINE KINASE INHIBITORS

Provided are compounds of Formula (I) which can be used as Syk inhibitors and potently as therapeutic agents against diseases mediated by Syk.

WEE1 inhibitors as well as preparation and application thereof

The invention relates to WEE1 inhibitors as well as preparation and application thereof. The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, solvates, polymorphs or isomers thereof, and their use in the preparation of medicaments for the treatment of diseases associated with WEE1 activity.