20949-84-2

Basic information

• Product Name: 4-FORMYL-2-METHYLTHIAZOLE
• Synonyms: IFLAB-BB F2124-0689;4-FORMYL-2-METHYLTHIAZOLE;4-THIAZOLECARBOXALDEHYDE, 2-METHYL-;2-METHYL-1,3-THIAZOLE-4-CARBALDEHYDE;2-Methyl-1,3-thiazole-4-carboxaldehyde;2-Methyl-1,3-thiazole-4-carboxaldehyde 97%;4-Formyl-2-methyl-1,3-thiazole;2-Methyl-4-thiazolecarboxaldehyde
• CAS NO: 20949-84-2
• Molecular Formula: C₅H₅NOS
• Molecular Weight: 127.16
• EINECS: 1533716-785-6
• Product Categories: Building Blocks;Thiazole
• Mol File: 20949-84-2.mol
• Article Data: 25

Chemical Properties

• Melting Point: 56-58
• Boiling Point: 219 °C at 760 mmHg
• Flash Point: 110℃
• Appearance: /
• Density: 1.27 g/cm³
• Vapor Pressure: 0.122mmHg at 25°C
• Refractive Index: 1.601
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.22±0.10(Predicted)
• CAS DataBase Reference: 4-FORMYL-2-METHYLTHIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FORMYL-2-METHYLTHIAZOLE(20949-84-2)
• EPA Substance Registry System: 4-FORMYL-2-METHYLTHIAZOLE(20949-84-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 20949-84-2(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Powder

InChI:InChI=1/C5H5NOS/c1-4-6-5(2-7)3-8-4/h2-3H,1H3

Upstream product

• 20949-79-5 4-dibromomethyl-2-methyl-thiazole 
• 6436-59-5 ethyl 2-methylthiazole-4-carboxylate 
• 77470-53-2 4-chloromethyl-2-methylthiazole hydrochloride 
• 76632-23-0 4-(hydroxymethyl)-2-methylthiazole 
• 39238-07-8 4-(chloromethyl)-2-methyl-1,3-thiazole 
• 22584-59-4 4-dibromomethyl-2-methyl-4,5-dihydro-thiazol-4-ol; hydrobromide 
• 721455-02-3 N-methoxy-N,2-dimethylthiazole-4-carboxamide 
• 79-37-8 oxalyl dichloride 
• 67-68-5 dimethyl sulfoxide 
• 108-18-9 diisopropylamine 
• 6436-60-8 methyl 2-methyl-1,3-thiazole-4-carboxylate 

Downstream Products

• 23002-78-0 4-acetyl-2-methylthiazole 
• 80378-02-5 1-(2-Hydroxyphenyl)-3-(2-methyl-4-thiazolyl)propenone 
• 80378-09-2 1-(2-Hydroxy-5-methoxyphenyl)-3-(2-methyl-4-thiazolyl)propenone 
• 80378-03-6 1-(2-Hydroxy-4-methoxyphenyl)-3-(2-methyl-4-thiazolyl)propenone 
• 80378-06-9 1-(2-Hydroxy-5-methylphenyl)-3-(2-methyl-4-thiazolyl)propenone 
• 80378-07-0 1-(5-Chloro-2-hydroxyphenyl)-3-(2-methyl-4-thiazolyl)propenone 
• 80378-05-8 1-(2-Hydroxy-4-methylphenyl)-3-(2-methyl-4-thiazolyl)propenone 
• 127942-32-9 2-(2-methyl-4-thiazolyl)imidazole 
• 80378-04-7 1-(4,5-Dimethyl-2-hydroxyphenyl)-3-(2-methyl-4-thiazolyl)propenone 
• 80378-11-6 1-(2-Benzyloxyphenyl)-3-(2-methyl-4-thiazolyl)-1-propenone 
• 80378-14-9 1-(2-Benzyloxy-5-chlorophenyl)-3-(2-methyl-4-thiazolyl)propenone 
• 80388-18-7 1-(2-Hydroxy-3-methylphenyl)-3-(2-methyl-4-thiazolyl)propenone 
• 80378-12-7 1-(2-Benzyloxy-4-methoxyphenyl)-3-(2-methyl-4-thiazolyl)propenone 
• 107263-89-8 (2-Methyl-4-thiazolyl)acetylene 

Relevant articles and documents

Synthesis and S(RN)1 reactions in 5-nitrothiazole series

A new heterocyclic reductive alkylating agent, the 2-methyl-4-chloromethyl-5-nitrothiazole, has been synthesized and could react with the 2-nitropropane anion as nucleophile, to give the 2-methyl-4-(2-methylpropenyl)-5-nitrothiazole as the major product.

Synthesis of new 1,4-dihydropyridine derivatives containing thiazolyl substituents

A series of 4-[2-methyl (or aryl) thiazole-4-yl]-2,6-dimethyl-3,5-diacetyl (or dibenzoyl) 1,4-dihydropyridines were synthesized using a modified Hantzsch reaction involving the condensation of the corresponding aldehyde with acetyl acetone or benzoyl acetone. The preparation of the corresponding aldehydes (2-methylthiazole-4-carboxaldehyde and some 2-arylthiazole-4-carboxaldehydes) was achieved by a simplified protocol of the published synthesis.

Design and synthesis C6-C8 bridged epothilone a

A conformationally restrained epothilone A analogue (3) with a short bridge between methyl groups at C6 and C8 was designed and synthesized. Preliminary biological evaluation indicates 3 to be only weakly active (IC50 = 8.5 μM) against the A2780 human ovarian cancer cell line.