20985-42-6Relevant articles and documents
A novel approach to isomeric pure (±)-methadone
Bracher, Franz,Klein, Katrin,Litz, Thomas
, p. 271 - 278 (2007/10/03)
Alkylation of deprotonated diphenylacetonitrile (2) with an acetal of chloroacetone followed by acidic hydrolysis and reductive amination of the resulting ketonitrile 12 offered an easy access to the methadone precursor 3. By this pathway the formation of the undesired regioisomer 4 was avoided.