209911-63-7

Basic information

• Product Name: 4'-(Dibromomethyl)-[1,1'-Biphenyl]-2-Carbonitrile
• Synonyms: 2'-Cyano-4-(dibroMoMethyl)-1,1'-biphenyl;2'-Cyano-4-(dibroMoMethyl)biphenyl;4,4-DibroMoMethyl-2'-cyanobiphenyl;4'-(Dibromomethyl);4'-(Dibromomethyl)-[1,1'-Biphenyl]-2-Carbonitrile;[1,1'-Biphenyl]-2-carbonitrile, 4'-(dibromomethyl)-;2-(4-DibroMoMethylphenyl)benzonitrile;Valsartan Impurity 30
• CAS NO: 209911-63-7
• Molecular Formula: C₁₄H₉Br₂N
• Molecular Weight: 351.03596
• Mol File: 209911-63-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 442.4±45.0 °C(Predicted)
• Appearance: /
• Density: 1.72±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Chloroform (Slightly), Methanol (Slightly, Sonicated)
• CAS DataBase Reference: 4'-(Dibromomethyl)-[1,1'-Biphenyl]-2-Carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-(Dibromomethyl)-[1,1'-Biphenyl]-2-Carbonitrile(209911-63-7)
• EPA Substance Registry System: 4'-(Dibromomethyl)-[1,1'-Biphenyl]-2-Carbonitrile(209911-63-7)

Safety Data

• Hazardous Substances Data: 209911-63-7(Hazardous Substances Data)

Usage

Uses

A di-substituted biphenol derivative.

Upstream product

• 114772-53-1 2-Cyano-4'-methylbiphenyl 
• 3839-22-3 2-cyanobenzoic acid 
• 131-63-5 ammonium 2-(aminocarbonyl)benzoate 

Downstream Products

• 139481-38-2 methyl 2-amino>-3-nitrobenzoate 
• 135689-93-9 4-(2-Cyanophenyl)benzaldehyde 
• 138401-24-8 4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-[1,1'-biphenyl]-2-carbonitrile 
• 114772-53-1 2-Cyano-4'-methylbiphenyl 

Relevant articles and documents

Readily Reconfigurable Continuous-Stirred Tank Photochemical Reactor Platform

A new modular photochemical continuous stirred-tank reactor (CSTR) design is described, based upon the development of light-source units that can be fitted to the previously described fReactor CSTR platform. In addition to use in homogeneous photochemical reactions (e.g., photoredox-catalyzed hydroamination), these units are especially well suited to handling multiphasic mixtures, exemplified here in solid-liquid (Wohl-Ziegler bromination) and gas-liquid (photocatalytic oxidative decarboxylation) reactions. The use of slurries as input feeds allows for the intensification of photochemical brominations, while the modular nature of the system facilitates the simple integration of downstream reaction steps, exemplified here in a continuous synthesis of an intermediate for the antihypertensive drug valsartan.

Synthesis of valsartan via decarboxylative biaryl coupling

(Chemical Equation Presented) An efficient synthesis of the angiotensin II inhibitor valsartan (Diovan) is presented. Two routes were evaluated, both making use of an advanced version of our decarboxylative coupling for the construction of the biaryl moiety. Thus, in the presence of a catalyst system consisting of copper(II) oxide, 1,10-phenanthroline, and palladium(II) bromide, 2-cyanocarboxylic acid was coupled with 1-bromo(4-dimethoxymethyl)benzene in 80% yield and with 4-bromotoluene in 71% yield. The valsartan synthesis using 1-bromo(4-dimethoxymethyl)benzene was completed in four steps overall with a total yield of 39%, via a novel route that presents substantial economical and ecological advantages over the literature process, as it is more concise and stoichiometric amounts of expensive organometallic reagents are avoided.

A process for producing an aralkyl compound, a dehalogenation method of an aralkyl halide compound and a method for recovering an aralkyl compound

The present invention provides a process for producing an aralkyl compound which comprises catalytically hydrogenating an aralkyl halide compound in a two-layer solvent system comprising water and water-insoluble organic solvent, a dehalogenation method of aralkyl halide compounds by subjecting to catalytic reduction in a two-layer solvent system comprising water and a water-insoluble organic solvent, and a method for recovering aralkyl compound from waste occurred in production of aralkyl halide compound by halogenation of aralkyl compound using the dehalogenation method.