209958-57-6

Basic information

• Product Name: 2-(3-cyano-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid ethyl ester
• Synonyms: 2-(3-cyano-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid ethyl ester
• CAS NO: 209958-57-6
• Molecular Weight: 255.276
• Mol File: 209958-57-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-(3-cyano-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-cyano-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid ethyl ester(209958-57-6)
• EPA Substance Registry System: 2-(3-cyano-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid ethyl ester(209958-57-6)

Safety Data

• Hazardous Substances Data: 209958-57-6(Hazardous Substances Data)

Upstream product

• 615-79-2 ethyl 2,4-diketopentanoate 
• 2881-99-4 3-cyano-phenylhydrazine hydrochloride 
• 209958-55-4 ethyl 1-(3-bromophenyl)-3-methyl-pyrazol-5-yl carboxylate 
• 17672-26-3 3-cyanophenyl hydrazine 
• 82874-96-2 2-methoxyimino-4-oxo-pentaneperoxoic acid ethyl ester 
• 2237-30-1 m-cyanoaniline 

Downstream Products

• 209958-59-8 1-(3-cyanophenyl)-N-[2'-(tert-butylaminosulfonyl) [1,1'-biphenyl]-4-yl]-3-methyl-1H-pyrazole-5-carboxamide 
• 209917-95-3 1-(3-cyanophenyl)-3-methylpyrazol-5-yl carboxylic acid chloride 
• 256512-36-4 2-(3-cyano-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid (2'-tert-butylsulfamoyl-biphenyl-4-yl)-methyl-amide 

Relevant articles and documents

CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF

Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.

NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS

The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula (I) or pharmaceutically acceptable salt or prodrug forms thereof, wherein J is N or NH and D may be C(=NH)NH2, which are useful as inhibitors of factor Xa.

Discovery of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2′-(methylsulfonyl)-[1,1′-b iphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable inhibitor of blood coagulation factor Xa

Factor Xa (fXa) plays a critical role in the coagulation cascade, serving as the point of convergence of the intrinsic and extrinsic pathways. Together with nonenzymatic cofactor Va and Ca2+ on the phospholipid surface of platelets or endotheli