209984-31-6

Basic information

• Product Name: 5-Methyl-5H-dibenz[b,d]azepine-6,7-dione 7-Oxime
• Synonyms: 5-Methyl-5H-dibenz[b,d]azepine-6,7-dione 7-Oxime;5H-Dibenz[b,d]azepine-6,7-dione, 5-Methyl-, 7-oxiMe;(E)-7-(Hydroxyimino)-5-methyl-5H-dibenzo[b,d]azepin-6(7H)-one
• CAS NO: 209984-31-6
• Molecular Formula: C₁₅H₁₂N₂O₂
• Molecular Weight: 252.26798
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 209984-31-6.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• Solubility: Ethanol, Methanol
• CAS DataBase Reference: 5-Methyl-5H-dibenz[b,d]azepine-6,7-dione 7-Oxime(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Methyl-5H-dibenz[b,d]azepine-6,7-dione 7-Oxime(209984-31-6)
• EPA Substance Registry System: 5-Methyl-5H-dibenz[b,d]azepine-6,7-dione 7-Oxime(209984-31-6)

Safety Data

• Hazardous Substances Data: 209984-31-6(Hazardous Substances Data)

Usage

Description

5-Methyl-5H-dibenz[b,d]azepine-6,7-dione 7-Oxime is an organic compound with the molecular formula C10H8N2O2. It is an off-white solid and serves as an intermediate in the preparation of γ-secretase inhibitors, which are important in the development of drugs targeting Alzheimer's disease.

Uses

Used in Pharmaceutical Industry:
5-Methyl-5H-dibenz[b,d]azepine-6,7-dione 7-Oxime is used as an intermediate in the synthesis of γ-secretase inhibitors for the development of drugs aimed at treating Alzheimer's disease. These inhibitors play a crucial role in modulating the production of amyloid-beta peptides, which are associated with the progression of the disease.
Used in Chemical Research:
As an off-white solid, 5-Methyl-5H-dibenz[b,d]azepine-6,7-dione 7-Oxime can also be utilized in various chemical research applications, particularly in the study of γ-secretase enzyme activity and the development of novel compounds with potential therapeutic benefits.

Upstream product

• 209984-30-5 N-methyl-5H-dibenzo[b,d]azepin-6(7H)-one 
• 20011-90-9 5H,7H-dibenzo[b,d]azepin-6-one 
• 40400-15-5 2-(2-iodophenyl)acetonitrile 
• 615-36-1 2-bromoaniline 
• 325141-76-2 2-{2'-amino-[1,1'-biphenyl]-2-yl}acetonitrile 
• 683277-81-8 (2'-azido-biphenyl-2-yl)-acetonitrile 
• 683277-82-9 (2'-azido-biphenyl-2-yl)-acetic acid 
• 683277-83-0 (2'-azido-biphenyl-2-yl)-acetic acid pentafluorophenyl ester 

Downstream Products

• 213024-76-1 7-amino-5-methyl-5H-dibenzo[b,d]azepin-6(7H)-one hydrochloride 
• 209994-99-0 7-(L-alaninyl)-amino-5-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one 

Relevant articles and documents

CYCLOALKYL, LACTAM, LACTONE AND RELATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS

Disclosed are compounds which inhibit beta -amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits beta -amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

Polycyclic α-amino-ε-caprolactams and related compounds

Disclosed are polycyclic α-amino-ε-caprolactams and related compounds which are useful as synthetic intermediates in the preparation of inhibitors of β-amyloid peptide release and/or its synthesis.

Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds

Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.