209986-17-4 Usage
Description
γ-Secretase Inhibitor XXI is a cell-permeable, potent, selective, peptidomimetic, and non-transition-state analog inhibitor of γ-secretase and Notch processing. It is designed to modulate the activity of γ-secretase, an enzyme complex that plays a crucial role in the processing of various cellular proteins, including the Notch receptor. This inhibition can have significant implications in the treatment of certain diseases and conditions.
Uses
Used in Pharmaceutical Industry:
γ-Secretase Inhibitor XXI is used as a therapeutic agent for targeting the γ-secretase enzyme, which is implicated in the pathogenesis of various neurodegenerative diseases such as Alzheimer's disease. By inhibiting γ-secretase, this compound can potentially reduce the formation of amyloid-beta peptides, which are known to aggregate and form plaques in the brains of Alzheimer's patients.
Additionally, γ-Secretase Inhibitor XXI is used as a research tool for studying the role of γ-secretase and Notch signaling in cellular processes and disease mechanisms. This can help researchers gain a better understanding of the molecular pathways involved and develop more targeted and effective treatments for related conditions.
Used in Drug Development:
γ-Secretase Inhibitor XXI serves as a lead compound in the development of novel drugs targeting γ-secretase for the treatment of Alzheimer's disease and other related neurodegenerative disorders. Its potent and selective inhibition of γ-secretase makes it a valuable starting point for the design and optimization of new therapeutic agents with improved efficacy and safety profiles.
Check Digit Verification of cas no
The CAS Registry Mumber 209986-17-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,9,9,8 and 6 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 209986-17:
(8*2)+(7*0)+(6*9)+(5*9)+(4*8)+(3*6)+(2*1)+(1*7)=174
174 % 10 = 4
So 209986-17-4 is a valid CAS Registry Number.
209986-17-4Relevant articles and documents
Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
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, (2008/06/13)
Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
