209991-62-8 Usage
Description
3,4,5-Trifluorophenylacetic acid is an organic compound characterized by the presence of three fluorine atoms on a phenyl ring, attached to an acetic acid group. This molecule is known for its potential applications in the pharmaceutical and chemical industries due to its unique structural properties and reactivity.
Uses
Used in Pharmaceutical Industry:
3,4,5-Trifluorophenylacetic acid is used as a key intermediate in the synthesis of Pteridinone compounds, which are essential for the treatment of cellular proliferative disorders. These compounds play a crucial role in modulating the growth and proliferation of cells, making them valuable in the development of therapeutic strategies for various diseases.
In the preparation of Pteridinone compounds, 3,4,5-Trifluorophenylacetic acid serves as a building block that can be further modified and functionalized to create molecules with specific biological activities. The presence of the fluorine atoms on the phenyl ring enhances the lipophilicity and metabolic stability of the resulting compounds, which can lead to improved drug efficacy and reduced side effects.
Overall, 3,4,5-Trifluorophenylacetic acid is a versatile and valuable compound in the pharmaceutical industry, particularly for the development of novel therapeutic agents targeting cellular proliferative disorders. Its unique structural features and reactivity make it an attractive candidate for further research and development in the field of medicinal chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 209991-62-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,9,9,9 and 1 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 209991-62:
(8*2)+(7*0)+(6*9)+(5*9)+(4*9)+(3*1)+(2*6)+(1*2)=168
168 % 10 = 8
So 209991-62-8 is a valid CAS Registry Number.
InChI:InChI=1/C8H5F3O2/c9-5-1-4(3-7(12)13)2-6(10)8(5)11/h1-2H,3H2,(H,12,13)
209991-62-8Relevant articles and documents
Preparation method of fluorophenylacetic acid
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Paragraph 0094; 0095; 0097, (2017/08/24)
The invention relates to the field of chemical synthesis, and particularly relates to a preparation method of fluorophenylacetic acid. The invention provides a preparation method of fluorophenylacetic acid. The preparation method comprises the following steps: diazotization addition reaction: enabling a compound of the formula II to react in a system containing vinylidene chloride, acid, a diazonino reagent, a phase transfer catalyst and a copper catalyst to produce a compound of the formula III; and hydrolysis reaction: hydrolyzing the compound of the formula III to produce a compound of the formula I under the existence condition of acid. The preparation method is simply and easily available in raw materials, simple and convenient to operate, low in raw material cost, mild in reaction conditions, and low in danger, free from the use of high-price noble metal catalyst and complicated industrial operation means, and the quality of the product is stable, and therefore, the preparation method is suitable for industrial large-scale production.
