21022-18-4

Basic information

• Product Name: N,N'-Bis-(2,4-dimethoxy-phenyl)-oxalamide
• Synonyms: N,N'-Bis-(2,4-dimethoxy-phenyl)-oxalamide
• CAS NO: 21022-18-4
• Molecular Weight: 360.367
• Mol File: 21022-18-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N,N'-Bis-(2,4-dimethoxy-phenyl)-oxalamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N'-Bis-(2,4-dimethoxy-phenyl)-oxalamide(21022-18-4)
• EPA Substance Registry System: N,N'-Bis-(2,4-dimethoxy-phenyl)-oxalamide(21022-18-4)

Safety Data

• Hazardous Substances Data: 21022-18-4(Hazardous Substances Data)

Upstream product

• 79-37-8 oxalyl dichloride 
• 2735-04-8 2,4-Dimethoxyaniline 
• 95-92-1 oxalic acid diethyl ester 

Relevant articles and documents

CuI/Oxalic Diamide Catalyzed Coupling Reaction of (Hetero)Aryl Chlorides and Amines

A class of oxalic diamides are found to be effective ligands for promoting CuI-catalyzed aryl amination with less reactive (hetero)aryl chlorides. The reaction proceeds at 120 °C with K3PO4 as the base in DMSO to afford a wide range of (hetero)aryl amines in good to excellent yields. The bis(N-aryl) substituted oxalamides are superior ligands to N-aryl-N′-alkyl substituted or bis(N-alkyl) substituted oxalamides. Both the electronic nature and the steric property of the aromatic rings in ligands are important for their efficiency.