210303-05-2

Basic information

• Product Name: 3-(4-isopropylbenzylidene)indolin-2-one
• Synonyms: 3-(4-isopropylbenzylidene)indolin-2-one
• CAS NO: 210303-05-2
• Molecular Formula: C18H17 N O
• Molecular Weight: 263.33
• Mol File: 210303-05-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(4-isopropylbenzylidene)indolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-isopropylbenzylidene)indolin-2-one(210303-05-2)
• EPA Substance Registry System: 3-(4-isopropylbenzylidene)indolin-2-one(210303-05-2)

Safety Data

• Hazardous Substances Data: 210303-05-2(Hazardous Substances Data)

Upstream product

• 59-48-3 2-oxoindole 
• 122-03-2 (4-isopropylbenzaldehyde) 
• 541520-03-0 N-phenyl-4-isopropylcinnamamide 
• 4395-73-7 4-isopropylbenzylamine 

Relevant articles and documents

Synthesis of (E)-3-Alkylideneindolin-2-ones by an Iron-Catalyzed Aerobic Oxidative Condensation of Csp3–H Bonds of Oxindoles and Benzylamines

A novel synthetic route for the construction of (E)-3-alkylideneindolin-2-ones through iron-catalyzed aerobic oxidative condensation of oxindoles with benzylamines has been developed. This oxidative reaction involves a sequence of C–H activation, amine self-condensation, nucleophilic addition, and C–C double bond formation. The synthetic importance of this protocol has been demonstrated by preparing tyrosine kinase inhibitors, anticonvulsant and antitumor agents, and other valuable 3-alkylideneindolin-2-one derivatives. Key intermediates are isolated and a plausible mechanistic pathway for the reaction has been discussed.

Oxindole synthesis by palladium-catalysed aromatic C-H alkenylation

A strategy involving palladium-catalysed aromatic C-H functionalisation/ intramolecular alkenylation provides a convenient and direct synthesis of 3-alkylideneoxindoles. In the presence of 5 mol% of PdCl2MeCN 2 and AgOCOCF3, a wide variety of N-cinnamoylanilines gave 3-alkylideneoxindoles in moderate to good yield. The Royal Society of Chemistry.