21031-22-1

Basic information

• Product Name: 1H-Pyrazole-4-carboxylic acid, 3-phenyl-, methyl ester
• CAS NO: 21031-22-1
• Molecular Formula: C11H10N2O2
• Molecular Weight: 202.213
• Mol File: 21031-22-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazole-4-carboxylic acid, 3-phenyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-4-carboxylic acid, 3-phenyl-, methyl ester(21031-22-1)
• EPA Substance Registry System: 1H-Pyrazole-4-carboxylic acid, 3-phenyl-, methyl ester(21031-22-1)

Safety Data

• Hazardous Substances Data: 21031-22-1(Hazardous Substances Data)

Usage

Chemical structure

A heterocyclic compound containing a pyrazole ring with a carboxylic acid group and a phenyl substituent.

Type of compound

Methyl ester derivative of 1H-pyrazole-4-carboxylic acid.

Usage

Commonly used in pharmaceutical research and development.

Potential applications

As a building block for the synthesis of new drug candidates in medicinal chemistry.

Suitability

Structure and properties make it suitable for the modification of existing pharmaceutical compounds or the development of novel therapeutic agents.

Biological activity

Has potential biological activity, contributing to its value in drug discovery and development processes.

Upstream product

• 5504-65-4 3-phenyl-1H-pyrazole-4-carboxylic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 772-62-3 3,3,3-trifluoro-1-phenylpropyne 
• 97602-40-9 methyl (E)-3-(5-phenyl-2H-1,2,3,4-tetraazol-2-yl)-2-propenoate 
• 67-56-1 methanol 
• 96256-52-9 3-Phenyl-4-trifluoromethyl-1H-pyrazole 
• 186581-53-3 diazomethane 
• 7299-58-3 phenylpropiolyl chloride 
• 4891-38-7 phenylpropynoic acid methyl ester 

Downstream Products

• 5504-65-4 3-phenyl-1H-pyrazole-4-carboxylic acid 
• 80326-71-2 methyl 1-methyl-5-phenyl-1H-pyrazole-4-carboxylate 
• 90145-22-5 1-Methyl-3-phenylpyrazol-4-carbonsaeure-methylester 
• 1246895-08-8 methyl 1-(5-fluoropyridin-2-yl)-3-phenyl-1H-pyrazole-4-carboxylate 

Relevant articles and documents

P2X3 RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN

The subject invention relates to novel P2X3 receptor antagonists that play a critical role in treating disease states associated with pain, in particular peripheral pain, inflammatory pain, or tissue injury pain that can be treated using a P2X

Two-step Synthesis of Imidazoles from Activated Alkynes

Conjugate addition of 2-(tri-n-butylstannyl)tetrazoles (1) to activated alkynes gives 1-alkenyltetrazoles (4) and (5) predominantly.Use of the N-tributylstannyl derivatives, rather than the parent tetrazole, gives a high ratio of 1- to 2-alkenyl isomers and avoids the complication of further addition of the tetrazole or the alkyne to the initial adduct.Irradiation of the (Z)- and (E)-1-alkenyltetrazoles (4) and (5) at 254 nm then gives the expected imidazoles in moderate yield.However, 5-phenyl-2-(tri-n-butylstannyl)tetrazole (1a) reacted only slowly with ethyl phenylpropiolate to give ethyl 3,5-diphenylpyrazole-4-carboxylate (8), presumably via the 2-alkenyltetrazole (9) formed in preference to the 1-isomer for steric reasons.

REACTIONS OD DIAZOALKANES WITH PHENYL- AND (TRIMETHYLSILYL)-PROPIOLOYL CHLORIDES

-