210345-56-5

Basic information

• Product Name: 5-Bromoindole-2-carboxylic acid methyl ester
• Synonyms: 5-BROMOINDOLE-2-CARBOXYLIC ACID METHYL ESTER;1H-Indole-2-carboxylic acid, 5-broMo-, Methyl ester;ZERO/005613;ZINC00499439;Methyl 5-bromoindole-2-carboxyate
• CAS NO: 210345-56-5
• Molecular Formula: C₁₀H₈BrNO₂
• Molecular Weight: 254.08
• Mol File: 210345-56-5.mol
• Article Data: 18

Chemical Properties

• Melting Point: 211.8-213.6 °C(Solv: toluene (108-88-3))
• Boiling Point: 386.2 °C at 760 mmHg
• Flash Point: 187.3 °C
• Appearance: /
• Density: 1.629 g/cm³
• Vapor Pressure: 3.61E-06mmHg at 25°C
• Refractive Index: 1.666
• Storage Temp.: 2-8°C
• PKA: 14.01±0.30(Predicted)
• CAS DataBase Reference: 5-Bromoindole-2-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromoindole-2-carboxylic acid methyl ester(210345-56-5)
• EPA Substance Registry System: 5-Bromoindole-2-carboxylic acid methyl ester(210345-56-5)

Safety Data

• Hazardous Substances Data: 210345-56-5(Hazardous Substances Data)

Usage

General Description

5-Bromoindole-2-carboxylic acid methyl ester is a chemical compound with the formula C10H8BrNO2. It is a derivative of indole, a heterocyclic aromatic compound. 5-Bromoindole-2-carboxylic acid methyl ester is commonly used in organic synthesis and medicinal chemistry as a building block for the synthesis of various biologically active compounds. It is also used in the production of pharmaceuticals, agrochemicals, and other fine chemicals. 5-Bromoindole-2-carboxylic acid methyl ester is a versatile and useful chemical with a wide range of applications in the field of chemistry and pharmaceuticals.

InChI:InChI=1/C10H8BrNO2/c1-14-10(13)9-5-6-4-7(11)2-3-8(6)12-9/h2-5,12H,1H3

Upstream product

• 67-56-1 methanol 
• 7254-19-5 5-bromo-2-indolecarboxylic acid 
• 66416-72-6 4-bromo-2-iodoaniline 
• 55477-80-0 methyl 2-[(tert-butoxycarbonyl)amino]acrylate 
• 3132-99-8 m-bromobenzoic aldehyde 
• 1586740-56-8 (Z)-methyl 3-(2-aminophenyl)-2-bromoacrylate 
• 1402454-70-9 methyl (Z)-2-bromo-3-(2-nitrophenyl)propenoate 
• 1586740-68-2 (Z)-methyl 3-(2-amino-5-bromophenyl)-2-bromoacrylate 
• 552-89-6 2-nitro-benzaldehyde 
• 956903-53-0 methyl 2-(4-bromophenylhydrazono)propionate 
• 622-88-8 4-bromophenylhydrazine hydrochloride 

Downstream Products

• 1179587-99-5 methyl 5-bromo-3-(3,4,5-trimethoxybenzoyl)-1H-indole-2-carboxylate 
• 20948-71-4 5-bromo-indole-2-carbohydrazide 
• 1609930-25-7 ethyl 5-bromo-3-(2,2,2-trifluoro-1-hydroxy-1-phenylethyl)-1H-indol-2-ylcarbamate 

Relevant articles and documents

A Bu4N[Fe(CO)3(NO)]-Catalyzed Hemetsberger–Knittel Indole Synthesis

The nucleophilic Fe complex Bu4N[Fe(CO)3(NO)] (TBA[Fe]) catalyzes the direct intramolecular amination of aryl vinyl azides to give the corresponding indole derivatives in good to excellent yields.

THERAPEUTIC COMPOUNDS AND METHODS TO TREAT INFECTION

Disclosed herein are compounds of formula (I), or a salt thereof and compositions comprising compounds of formula I that exhibit antibacterial activities, when tested alone and/or in combination with a bacterial efflux pump inhibitor. Also disclosed are methods of treating or preventing a bacterial infection in an animal comprising administering to the animal a compound of formula I alone or in combination with the administration of a bacterial efflux pump inhibitor.

BACTERIAL EFFLUX PUMP INHIBITORS

Disclosed herein are compounds of formula I and salts thereof. Also disclosed are compositions comprising compounds of formula I and methods using compounds of formula I.