21038-25-5

Basic information

• Product Name: O-(4-butoxybenzyl)hydroxylamine
• Synonyms: Hydroxylamine, O-(p-butoxybenzyl)-; O-(p-Butoxybenzyl)hydroxylamine
• CAS NO: 21038-25-5
• Molecular Formula: C₁₁H₁₇NO₂
• Molecular Weight: 195.2582
• Mol File: 21038-25-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 328°C at 760 mmHg
• Flash Point: 161.1°C
• Density: 1.031g/cm³
• Vapor Pressure: 0.000194mmHg at 25°C
• Refractive Index: 1.514
• CAS DataBase Reference: O-(4-butoxybenzyl)hydroxylamine(CAS DataBase Reference)
• NIST Chemistry Reference: O-(4-butoxybenzyl)hydroxylamine(21038-25-5)
• EPA Substance Registry System: O-(4-butoxybenzyl)hydroxylamine(21038-25-5)

Safety Data

• Hazardous Substances Data: 21038-25-5(Hazardous Substances Data)

Upstream product

• 16115-52-9 O-p-Butoxy-benzylacethydroximsaeure-aethylester 
• 428455-37-2 2-(4-butoxy-benzyloxy)-isoindole-1,3-dione 
• 6214-45-5 (4-butoxyphenyl)methanol 

Downstream Products

• 867168-88-5 2-amino-3-hydroxy-propionaldehyde O-(4-butoxy-benzyl)-oxime 

Relevant articles and documents

A solid-phase approach to DDB derivatives

Since the discovery of 2,2′-dimethoxycarbonyl-4,4-dimethoxy-5,6, 5′,6′-biomethylenedioxy-biphenyl (DDB) as a potent anti-HBV agent, we have studied the structure-activity relationships of 4,4′-dimethoxy-5, 6,5′,6′-dimethenedioxy-2-alkyloxycarbonyl-2′-(4-substituted benzyl piperazin-1-yl)carbonyl-biphenyl as anti-HBV agents. Therefore, it is rational to extend this study to the 3,3′-disustituted-4,4′- dimethoxy-5,6,5′,6′-dimethenedioxy-2-alkyloxycarbonyl-2′- Serine derivatives. Thus, in an attempt to develop an efficient method for the preparation of a large number of DDB derivatives, the reaction between a DDB acid chloride and serine derivatives on solid support was studied. The structure of resulted compounds was confirmed by LC-MS and 1H NMR analysis. Compounds 2a, 2d, 2f, 2j showed in vitro anti-HBV activity without significant toxicity up to 100 μM.