21047-89-2 Usage
Description
Propanamide, N-(6,7-dihydro-6-oxo-1H-purin-2-yl)-2-methylis a chemical compound that features a propionic amide structure with a 6,7-dihydro-6-oxo-1H-purin-2-yl group attached to the nitrogen atom. Propanamide, N-(6,7-dihydro-6-oxo-1H-purin-2-yl)-2-methylis characterized by its ability to participate in enzymatic reactions, particularly in the transglycosylation of purine nucleobases, which is crucial for the synthesis of purine nucleosides.
Uses
Used in Pharmaceutical Industry:
Propanamide, N-(6,7-dihydro-6-oxo-1H-purin-2-yl)-2-methylis used as a key intermediate in the synthesis of purine nucleosides for the pharmaceutical industry. The compound plays a vital role in the enzymic transglycosylation of purine nucleobases, which is essential for the production of various therapeutic agents, including antiviral and anticancer drugs.
Used in Research and Development:
In the field of research and development, Propanamide, N-(6,7-dihydro-6-oxo-1H-purin-2-yl)-2-methylis utilized as a valuable compound for studying the mechanisms of enzymatic transglycosylation and the synthesis of purine nucleosides. This knowledge can contribute to the development of novel drugs and therapies for various diseases, particularly those related to nucleic acid metabolism and cellular signaling pathways.
Used in Biochemical Applications:
Propanamide, N-(6,7-dihydro-6-oxo-1H-purin-2-yl)-2-methylis also employed in various biochemical applications, such as the study of enzyme kinetics, enzyme inhibition, and the development of new biocatalysts for the synthesis of purine nucleosides and their derivatives. These applications can lead to advancements in the fields of biotechnology and chemical biology, ultimately benefiting human health and well-being.
Check Digit Verification of cas no
The CAS Registry Mumber 21047-89-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,0,4 and 7 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 21047-89:
(7*2)+(6*1)+(5*0)+(4*4)+(3*7)+(2*8)+(1*9)=82
82 % 10 = 2
So 21047-89-2 is a valid CAS Registry Number.
21047-89-2Relevant articles and documents
Observation of two N2-isobutyrylguanine tautomers by NMR spectroscopy
Yang, Lijing,Li, Jia,Simionescu, Razvan,Yan, Hongbin
, p. 60 - 64 (2013)
N2-Isobutyrylguanine was prepared by treatment of guanine with isobutyryl chloride. Two tautomers, 1,7-dihydro-2-(isobutyroyl)amino-6H-purin-6- one and 1,9-dihydro-2-(isobutyroyl)amino-6H-purin-6-one, were identified in almost 1: 1 ratio in dichloromethane-dimethyl sulfoxide (1: 1 v/v) by NMR spectroscopy. By using the selective-inversion experiments, enthalpy, entropy, and free energy for activation were determined. This work represents the first report of guanine tautomers observed directly by NMR spectroscopy. Copyright
A convenient route to synthesize N2-(isobutyryl)-9-(carboxymethyl)guanine for aeg-PNA backbone
Datta, Dhrubajyoti
, p. 530 - 541 (2019/11/03)
Synthesis of exclusive N2-(isobutyryl)-9-(carboxymethyl)guanine, an important moiety for peptide nucleic acid synthesis has been reported through a high-yielding reaction scheme starting from 6-chloro-2-amino purine. Crystal structures of two intermediates confirmed the formation of N9-regioisomer. This new synthetic route can potentially replace the conventional tedious method with moderate overall yield.
Synthesis of 3-guaninyl- and 3-adeninyl-5-hydroxymethyl-2-pyrrolidinone nucleosides
Saleh, Abdullah,D'Angelo, John G.,Morton, Martha D.,Quinn, Jesse,Redden, Kendra,Mielguz, Rafal W.,Pavlik, Christopher,Smith, Michael B.
scheme or table, p. 5574 - 5583 (2011/10/02)
l- And d-glutamic acids, as well as trans-4-hydroxy-l-proline, are converted to the corresponding 3-guaninyl-5-hydroxymethyl-2-pyrrolidinone (4) or 3-adeninyl-5-hydroxymethyl-2-pyrrolidinone (5) nucleoside analog. The protecting group used to block the lactam nitrogen in key intermediates has a significant effect on the diastereoselectivity of the coupling reaction with adenine or guanine.
