21053-95-2

Basic information

• Product Name: 2(5H)-Furanone, 4-hydroxy-5-methyl-3-phenyl-
• CAS NO: 21053-95-2
• Molecular Formula: C11H10O3
• Molecular Weight: 190.199
• Mol File: 21053-95-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2(5H)-Furanone, 4-hydroxy-5-methyl-3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(5H)-Furanone, 4-hydroxy-5-methyl-3-phenyl-(21053-95-2)
• EPA Substance Registry System: 2(5H)-Furanone, 4-hydroxy-5-methyl-3-phenyl-(21053-95-2)

Safety Data

• Hazardous Substances Data: 21053-95-2(Hazardous Substances Data)

Upstream product

• 100613-09-0 2-phenylacetoxy-propionic acid ethyl ester 
• 103-82-2 phenylacetic acid 
• 4439-87-6 2-phenyllevulinic acid 
• 55091-68-4 3-phenyl-5-methyl-2,5-dihydrofuran-2-one 
• 41309-99-3 2-<(trimethylsilyl)oxy>propanenitrile 
• 2882-19-1 ethyl 2-phenyl-2-bromoacetate 

Downstream Products

• 1589533-12-9 C₁₂H₁₂O₃ 
• 1589533-22-1 3-phenyl-5-(hydroxymethyl)-4-methoxyfuran-2(5H)-one 
• 1589532-51-3 3-phenyl-7a-methyl-7,7a-dihydrofuran[3,2-d][1,2]oxathin-5,5-dioxide-2(4H)-one 
• 1589533-33-4 C₁₄H₁₆O₆S 

Relevant articles and documents

Synthesis and anti-BVDV activity of novel δ-sultones in vitro: Implications for HCV therapies

In this study we report the synthesis and activity against bovine viral diarrhea virus (BVDV) of a novel series of bicycle δ-sultones containing γ-lactones. BVDV is responsible for major losses in cattle. Some of the synthesized δ-sultones showed pronounced anti-BVDV activity with EC 50 values of 0.12-1.0 μM and no significant cytotoxicity. Among them, the ortho bromosubstituted derivative 4f (EC50 = 0.12 μM) showed better antiviral activity than other derivatives and was 10 fold more that of than positive control ribavirin (EC50 = 1.3 μM). BVDV is also considered to be a valuable surrogate for the hepatitis C virus (HCV) in antiviral drug studies. The above results provided a novel candidate for the development of anti-HCV agents.

Photochemical and Lewis-acid-catalyzed rearrangement of 1-phenyl-4-methyl-3,6-dioxabicyclohexan-2-one into its tetronic acid isomer

The irradiation of 2 in acetonitrile or methanol with λ 254 nm yields the tetronic acid derivative 3.The (thermal) BF3-catalyzed rearrangement of 2 yields the same tetronic acid derivative.The structure of the tetronic acid 3 has been determined by means of X-ray analysis; it forms monoclinic crystals with cell constants a=10.868, b=8.320, c=20.936 Angstroem and β=90.56 deg.The space group is P21/n; in the unit cell there are eight molecules which exhibit intermolecular hydrogen bonding.