210561-40-3

Basic information

• Product Name: Hydroxymethyl-((R)-1-hydroxymethyl-2-phenyl-ethyl)-carbamic acid tert-butyl ester
• Synonyms: Hydroxymethyl-((R)-1-hydroxymethyl-2-phenyl-ethyl)-carbamic acid tert-butyl ester
• CAS NO: 210561-40-3
• Molecular Weight: 281.352
• Mol File: 210561-40-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Hydroxymethyl-((R)-1-hydroxymethyl-2-phenyl-ethyl)-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Hydroxymethyl-((R)-1-hydroxymethyl-2-phenyl-ethyl)-carbamic acid tert-butyl ester(210561-40-3)
• EPA Substance Registry System: Hydroxymethyl-((R)-1-hydroxymethyl-2-phenyl-ethyl)-carbamic acid tert-butyl ester(210561-40-3)

Safety Data

• Hazardous Substances Data: 210561-40-3(Hazardous Substances Data)

Upstream product

• 210561-38-9 (R)-4-Benzyl-5-oxo-oxazolidine-3-carboxylic acid tert-butyl ester 
• 50-00-0 formaldehyd 
• 106454-69-7 N-tert-butoxycarbonyl-D-Phenylalaninol 

Downstream Products

• 5267-64-1 (R)-2-amino-3-phenylpropanol 
• 106454-69-7 N-tert-butoxycarbonyl-D-Phenylalaninol 

Relevant articles and documents

N-hydroxymethyl group for configurationally stable N-alkoxycarbonyl α- amino aldehydes [1]

Attachment of an N-hydroxymethyl group to N-Boc-α-amino aldehyde enhanced greatly the configurational stability of the stereogenic carbon α to the aldehyde group by shifting the equilibrium from an open form of ω- hydroxyaldehyde to a closed form of hemiacetal. The N-hydroxymethyl group was introduced by treating N-Boc-α-amino acids with formaldehyde in the presence of an acid catalyst followed by reduction with DIBALH.