210827-34-2

Basic information

• Product Name: 2-Furansulfonamide, 4-(1-hydroxy-1-methylethyl)-
• CAS NO: 210827-34-2
• Molecular Formula: C7H11NO4S
• Molecular Weight: 205.235
• Mol File: 210827-34-2.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-Furansulfonamide, 4-(1-hydroxy-1-methylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Furansulfonamide, 4-(1-hydroxy-1-methylethyl)-(210827-34-2)
• EPA Substance Registry System: 2-Furansulfonamide, 4-(1-hydroxy-1-methylethyl)-(210827-34-2)

Safety Data

• Hazardous Substances Data: 210827-34-2(Hazardous Substances Data)

Upstream product

• 75-16-1 methylmagnesium bromide 
• 13129-23-2 methyl furan-3-carboxylate 
• 256373-94-1 ethyl 5-sulfamoylfuran-3-carboxylate 
• 676-58-4 methylmagnesium chloride 

Downstream Products

• 210826-40-7 MCC950 

Relevant articles and documents

SULFONIMIDAMIDE COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY

In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured: (Formula AA) or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula A can be as defined anywhere herein.

SULPHONAMIDES AND COMPOSITIONS THEREOF FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY

In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured: wherein the variables shown in Formula AA can be as defined anywhere herein. Compounds AA are modulators of NLRP1 and/or NLRP3

Chemoselective Removal of Dimeric 1,3-Diol Impurities Generated from Methyl Grignard Addition onto Esters

In two separate cases, we have found that 1,3-diol dimeric impurities were common byproducts generated from the methyl Grignard addition onto esters to form the corresponding tertiary alcohols. These impurities proved difficult to purge by recrystallization as they tended to cocrystallize with the desired product. To avoid the necessity of chromatography, we developed a practical procedure for the chemoselective removal of these 1,3-diol impurities from crude tertiary alcohol by simply performing the recrystallization in the presence of phenylboronic acid. This straightforward method proved equally successful for two cases studied, and the procedure was later demonstrated on a multikilogram scale.