21092-94-4

Basic information

• Product Name: Ethanone, 1-[3-hydroxy-4-(phenylMethoxy)phenyl]-
• Synonyms: Ethanone, 1-[3-hydroxy-4-(phenylMethoxy)phenyl]-;1-(4-(benzyloxy)-3-hydroxyphenyl)ethanone
• CAS NO: 21092-94-4
• Molecular Formula: C₁₅H₁₄O₃
• Molecular Weight: 242.26986
• Mol File: 21092-94-4.mol
• Article Data: 10

Chemical Properties

• Melting Point: 118°C
• Appearance: /
• CAS DataBase Reference: Ethanone, 1-[3-hydroxy-4-(phenylMethoxy)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-[3-hydroxy-4-(phenylMethoxy)phenyl]-(21092-94-4)
• EPA Substance Registry System: Ethanone, 1-[3-hydroxy-4-(phenylMethoxy)phenyl]-(21092-94-4)

Safety Data

• Hazardous Substances Data: 21092-94-4(Hazardous Substances Data)

Usage

Preparation

Preparation by reaction of benzyl chloride with 3,4-di-hydroxyacetophenone in the presence of potassium hydroxide in a refluxing mixture of ethanol, methanol and water (53%).

Upstream product

• 1197-09-7 1-(3,4-dihydroxyphenyl)ethan-1-one 
• 100-44-7 benzyl chloride 
• 3162-29-6 1-(benzo[d][1,3]dioxol-6-yl)ethanone 
• 20194-18-7 sodium phenyl-methanolate 
• 100-39-0 benzyl bromide 
• 498-02-2 1-(3-methoxy-4-hydroxyphenyl)ethanone 

Downstream Products

• 1835-11-6 4-benzyloxy-3-methoxyacetophenone 
• 101728-71-6 1-[4-benzyloxy-3-(3-chloro-2-hydroxy-propoxy)-phenyl]-ethanone 
• 21092-96-6 1-(4-benzyloxy-3-hydroxy-phenyl)-2-bromo-ethanone 
• 63437-95-6 1-[4-Benzyloxy-3-(2,3-dihydroxy-propoxy)-phenyl]-ethanone 
• 63437-93-4 1-[4-Benzyloxy-3-(2-hydroxy-propoxy)-phenyl]-ethanone 
• 63437-84-3 1-[4-Benzyloxy-3-(2-hydroxy-ethoxy)-phenyl]-ethanone 
• 1027294-59-2 tert-butyl <5-acetyl-2-<(trifluoromethyl)sulfonyloxy>phenoxy>acetate 
• 1025992-97-5 [2-Benzyloxy-5-((E)-2-diethylcarbamoyl-1-methyl-vinyl)-phenoxy]-acetic acid ethyl ester 
• 100863-83-0 1-(3-hexyloxy-4-hydroxy-phenyl)-ethanone 
• 100127-01-3 1-[3-(3-chloro-2-hydroxy-propoxy)-4-hydroxy-phenyl]-ethanone 
• 63437-85-4 1-[4-Hydroxy-3-(2-hydroxy-ethoxy)-phenyl]-ethanone 
• 63437-94-5 1-[4-Hydroxy-3-(2-hydroxy-propoxy)-phenyl]-ethanone 
• 70064-44-7 1-[3-(2,3-Dihydroxy-propoxy)-4-hydroxy-phenyl]-ethanone 
• 1399849-95-6 1-[4-(benzyloxy)-3-(3-methoxypropyloxy)phenyl]ethanone 

Relevant articles and documents

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Method for synthesizing houttuynine hybridized flavone Houttuynoid A

The invention discloses a method for synthesizing houttuynine hybridized flavone Houttuynoid A. The method mainly comprises the following steps: by taking 3,4-dihydroxy benzaldehyde as an initiator raw material, firstly, selectively protecting four-position hydroxyl, performing an iodination reaction so as to obtain an o-iodophenol structure; further protecting aldehyde by using 1,3-propylene glycol, performing a Michael addition reaction with methyl-2-undecynoate so as to obtain an intermittent, and further performing an intracellular Heck reaction on the intermittent so as to obtain a key intermittent 2,3-di-substituted benzofuran structure; deprotecting the aldehyde of the benzofuran structure, performing a Claisen-Schmidt reaction with trihydroxyacetophenone monohydrate so as to obtaina chalcone structure, further performing iodine-catalyzed ring closure and DMDO (Dimethyldioxirane) oxidation so as to obtain a flavonol structure, furthermore removing a protection group, further reacting with bromo-peracetylated galactose so as to obtain glucoside, finally removing all protection groups, and performing reduction, thereby obtaining a target compound, namely the houttuynine hybridized flavone Houttuynoid A. Related derivatives are synthesized through intermittents of synthesis routs. The method is simple and controllable in reaction and high in yield.

NOVEL RENIN INHIBITOR

The present invention provides a nitrogen-containing saturated heterocyclic compound of the formula [I] which is useful as a renin inhibitor. wherein R1 is a cycloalkyl group or an alkyl, R22 is an optionally substituted aryl and the like, R is a lower alkyl group, R3, R4, R5 and R6 are the same or different, and are a hydrogen atom, an optionally substituted carbamoyl, an optionally substituted alkyl, or alkoxycarbonyl, or a pharmaceutically acceptable salt thereof.