210980-68-0

Basic information

• Product Name: Dehydro Simvastatin
• Synonyms: Dehydro Simvastatin;2,2-DiMethylbutanoic Acid (1S,3R,7S,8S,8aR)-8-[2-[(2R)-3,6-Dihydro-6-oxo-2H-pyran -2-yl]ethyl]-1,2,3,7,8,8a-hexahydro-3,7-diMethyl-1-naphthalenyl Ester;SiMvastatin IMpurity-C;SiMvastatin EP IMpurity C;Anhydro SiMvastatin (SiMvastatin IMpurity C);(1S,3R,7S,8S,8aR)-3,7-dimethyl-8-(2-((R)-6-oxo-5,6-dihydro-2H-pyran-2-yl)ethyl)-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
• CAS NO: 210980-68-0
• Molecular Formula: C₂₅H₃₆O₄
• Molecular Weight: 400.55094
• Product Categories: Chiral Reagents;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 210980-68-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 536.8±50.0 °C(Predicted)
• Appearance: /
• Density: 1.07±0.1 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer
• Solubility: Acetonitrile (Slightly), Chloroform (Slightly), Ethyl Acetate (Slightly), Methan
• CAS DataBase Reference: Dehydro Simvastatin(CAS DataBase Reference)
• NIST Chemistry Reference: Dehydro Simvastatin(210980-68-0)
• EPA Substance Registry System: Dehydro Simvastatin(210980-68-0)

Safety Data

• Hazardous Substances Data: 210980-68-0(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Low Melting Solid

Uses

Dehydro Simvastatin (Simvastatin EP Impurity C) is a Simvastatin (S485000) impurity.

Upstream product

• 145576-24-5 C₂₁H₃₀O₅ 
• 5856-77-9 2,2-dimethylbutanoyl chloride 
• 850920-00-2 C₂₃H₃₂O₆ 
• 81189-92-6 (S)-2-methyl-butyric acid (3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-acetoxy-6-oxo-tetrahydro-pyran-2yl]-ethyl}-3,7-dimetyl-1,2,3,7,8,8a-hexahydro-naphthalen-1-yl ester 
• 29138-64-5 α,α-dimethylbutanoic anhydride 
• 151006-15-4 (4R,6R)-4-hydroxy-6-(2-((1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)ethyl)tetrahydro-2H-pyran-2-one 
• 145576-25-6 simvastatin acetate 

Relevant articles and documents

METHODS FOR MAKING SIMVASTATIN AND INTERMEDIATES

The invention provides synthetic chemical and chemoenzymatic methods of producing simvastatin and various intermediates. In one aspect, enzymes such as hydrolases, e.g., esterases, are used in the methods of the invention.