21099-08-1

Basic information

• Product Name: 2-bromo-6-(tert-butyl)-4-methoxyphenol
• Synonyms: 2-bromo-6-(tert-butyl)-4-methoxyphenol
• CAS NO: 21099-08-1
• Molecular Weight: 259.143
• Mol File: 21099-08-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-bromo-6-(tert-butyl)-4-methoxyphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-6-(tert-butyl)-4-methoxyphenol(21099-08-1)
• EPA Substance Registry System: 2-bromo-6-(tert-butyl)-4-methoxyphenol(21099-08-1)

Safety Data

• Hazardous Substances Data: 21099-08-1(Hazardous Substances Data)

Upstream product

• 121-00-6 3-tert-Butyl-4-hydroxyanisole 

Downstream Products

• 1415902-03-2 C₂₃H₂₅O₂P 
• 1222630-23-0 2-tert-butyl-4-methoxy-6-(octyltelluro)phenol 
• 1222630-22-9 2-tert-butyl-4-methoxy-6-(octylseleno)phenol 
• 1222630-21-8 2-tert-butyl-4-methoxy-6-(octylthio)phenol 
• 4950-33-8 2,6-di-tert-butyl-8-methoxydibenzofuran-1,4-dione 
• 14160-38-4 3,3'-di-tert-butyl-biphenyldiquinone-(2,5,2',5') 
• 1774-82-9 2-bromo-6-tert-butyl-1,4-dimethoxybenzene 

Relevant articles and documents

Total Synthesis of (+)-Erogorgiaene and the Pseudopterosin A?F Aglycone via Enantioselective Cobalt-Catalyzed Hydrovinylation

Due to their pronounced bioactivity and limited availability from natural resources, metabolites of the soft coral Pseudopterogorgia elisabethae, such as erogorgiaene and the pseudopterosines, represent important target molecules for chemical synthesis. We have now developed a particularly short and efficient route towards these marine diterpenes exploiting an operationally convenient enantioselective cobalt-catalyzed hydrovinylation as the chirogenic step. Other noteworthy C?C bond forming transformations include diastereoselective Lewis acid-mediated cyclizations, a Suzuki coupling and a carbonyl ene reaction. Starting from 4-methyl-styrene the anti-tubercular agent (+)-erogorgiaene (>98 % ee) was prepared in only 7 steps with 46 % overall yield. In addition, the synthesis of the pseudopterosin A aglycone was achieved in 12 steps with 30 % overall yield and, surprisingly, was found to exhibit a similar anti-inflammatory activity (inhibition of LPS-induced NF-κB activation) as a natural mixture of pseudopterosins A?D or iso-pseudopterosin A, prepared by β-D-xylosylation of the synthetic aglycone.

Yttrium phosphasalen initiators for rac -lactide polymerization: Excellent rates and high iso-selectivities

Highly active yttrium phosphasalen initiators for the stereocontrolled ring-opening polymerization of rac-lactide are reported. The initiators are coordinated by a new class of ancillary ligand: an iminophosphorane derivative of the popular "salen" ligand

OXIDATIVE COUPLING REACTION OF 2-HALOPHENOLS WITH K3Fe(CN)6 IN BENZENE SOLUTION

The oxidative coupling of twelve 2-halophenols (1a-1l) was carried out with K3Fe(CN)6 in benzene solution to obtain the corresponding dibenzofuran derivatives.However, only a small amount of the desired dibenzofurans such as 2,6-di-tert-butyl-8-methoxybenzofuran-1,4-quinone (9) and 4,8-di-tert-butyl-2,6-di-isopropyl-1-hydroxydibenzofuran (11) were obtained from 2-bromo-6-tert-butyl-4-methoxy- (1d) and 2-bromo-4-tert-butyl-6-isopropylphenol (1g), respectively.In the other cases, alternative type of products or tarry materials were formed.