211054-14-7

Basic information

• Product Name: (R)-2-(toluene-4-sulfonylamino)pent-4-ynoic acid
• Synonyms: (R)-2-(toluene-4-sulfonylamino)pent-4-ynoic acid
• CAS NO: 211054-14-7
• Molecular Weight: 267.306
• Mol File: 211054-14-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (R)-2-(toluene-4-sulfonylamino)pent-4-ynoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-(toluene-4-sulfonylamino)pent-4-ynoic acid(211054-14-7)
• EPA Substance Registry System: (R)-2-(toluene-4-sulfonylamino)pent-4-ynoic acid(211054-14-7)

Safety Data

• Hazardous Substances Data: 211054-14-7(Hazardous Substances Data)

Upstream product

• 718596-26-0 2-amino-4-pentynoic acid amide 
• 23235-01-0 (R)-2-aminopent-4-ynoic acid 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 437553-84-9 (R)-N-(1-hydroxymethylbut-3-ynyl)-4-methylbenzenesulfonamide 
• 885104-32-5 (R)-2-(4-methylbenzenesulfonamido)pent-4-ynamide 
• 885104-54-1 (R)-3-(1-((R)-7-formyl-3,4-dihydro-2H-chromen-4-yl)-1H-1,2,3-triazol-4-yl)-2-(4-methylbenzenesulfonamido)propanoic acid 
• 885105-36-2 (R)-N-(2,2-dimethoxyethyl)-2-(4-methylbenzenesulfonamido)pent-4-ynamide 
• 437553-86-1 (R)-N-[1-(tert-butyldimethylsilyloxymethyl)but-3-ynyl]-4-methylbenzenesulfonamide 

Relevant articles and documents

TRIAZOLES AND THEIR USE AS BRADYKININ B1 RECEPTOR ANTAGONISTS

Compounds of Formula (I): are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

Palladium-Catalyzed Cyclization Reactions of Acetylene-Containing Amino Acids

Enantiomerically pure acetylene-containing α-amino acids were used as versatile starting materials for the synthesis of a variety of heterocycles via Pd-mediated cyclization reactions. Depending on the protecting group strategy, both the carboxylate and the amine function of the amino acids could participate in the cyclizations, thus giving rise to oxygen heterocycles (α-aminolactones) and nitrogen heterocycles (cyclic α-amino acid derivatives), respectively. Beside the straightforward cyclization, cyclization/cross-coupling reactions were also successfully carried out to provide the corresponding substituted cyclic amino acid derivatives.