21120-43-4Relevant articles and documents
Synthesis and spectral properties of fluorinated α,β-epoxyphosphonates
Rapp, Magdalena,Margas-Musielak, Klaudia,Koroniak, Henryk
, p. 142 - 149 (2015)
The methods of synthesis of two type of monofluorinated α,β-epoxyphosphonates, fosfomycin analogues, with the vicinal and geminal arrangement of fluorine and phosphorus atoms have been developed. The electrophilic monofluorination of enamine or β-enaminop
Direct electrophilic α-fluorination of imines: Efficient synthesis of mono-and difluoroimines
Verniest, Guido,Van Hende, Eva,Surmont, Riccardo,De Kimpe, Norbert
, p. 4767 - 4770 (2007/10/03)
(Chemical Equation Presented) A mild and efficient procedure to synthesize α-fluoro- and α,α-difluoroimines was developed. Various N-alkylimines derived from acetophenones were successfully monofluorinated using NFSI (N-fluorobenzenesulfonimide) in a mixture of CH3CN and DMF at 0°C. Alternatively, the same procedure without DMF gave rise to difluorinated imines when performed at room temperature. The obtained α- and α,α-difluorinated imines were subsequently reduced to give the corresponding β-fluoro- and β,β-difluoroamines in good yield.
MONO ET DIFLUORATION ELECTROCHIMIQUES DE GROUPES BENZYLIQUES
Laurent, Eliane,Marquet, Bernard,Tardivel, Robert
, p. 4431 - 4444 (2007/10/02)
Anodic oxidation of benzylic compounds 1 using CH3CN as a solvent and Et3N,3HF as a fluorinating reagent allowed to introduce a fluorine atom in α position of electron withdrawing group via carbocation 1+ (ECBECN mechanism).Whatever the E group, monofluorides 2 are obtained in good yields from paramethoxy derivatives 1 (R=p-OCH3).In this case, by raising the potential of working electrode after the monofluorination step, gem difluorides 3 can be directly prepared from 1.When the substituent of the phenyl ring is different of a methoxy group, a mixture of fluoride 2 and acetamide 4 is generally obtained and the ratio of these two compounds is related to cation stability.
