211230-12-5Relevant articles and documents
Copper hydride catalyzed enantioselective conjugate reduction of unsaturated nitriles
Lee, Daehyung,Yang, Youngmin,Yun, Jaesook
, p. 2233 - 2235 (2007)
α,β-Unsaturated nitriles were reduced with high levels of enantioselectivity via copper hydride catalysis. In this procedure, bench-top stable copper(II) acetate and Josiphos ligand are used as the chiral catalyst and an inexpensive hydrosilane, polymethy
Asymmetric Umpolung Hydrogenation and Deuteration of Alkenes Catalyzed by Nickel
Guo, Siyu,Wang, Xiuhua,Zhou, Jianrong Steve
supporting information, p. 1204 - 1207 (2020/02/04)
Nickel-catalyzed asymmetric hydrogenation of several types of alkenes proceeds in high enantioselectivity, using acetic acid or water as the hydrogen source and indium powder as electron donor. The scope of alkenes herein include α,β-unsaturated esters, n
Highly efficient Rh-catalyzed asymmetric hydrogenation of α,β-unsaturated nitriles
Yan, Qiaozhi,Kong, Duanyang,Li, Meina,Hou, Guohua,Zi, Guofu
, p. 10177 - 10181 (2015/09/01)
A highly efficient enantioselective hydrogenation of α,β-unsaturated nitriles catalyzed by Rh-(R,R)-f-spiroPhos complex has been developed. With Rh-(R,R)-f-spiroPhos catalyst and under mild conditions, a wide range of α,β-unsaturated nitriles including the (E)- and (Z)-isomers of 3-alkyl-3-aryl, 3,3-diaryl, and 3,3-dialkyl α,β-unsaturated nitriles were hydrogenated to the corresponding chiral nitriles with excellent enantioselectivities (up to 99.9% ee) and high turnover numbers (TON up to 10,000).