21136-32-3

Basic information

• Product Name: 1,1-Dibenzyl-2-benzylidenehydrazine
• Synonyms: 1,1-Dibenzyl-2-benzylidenehydrazine;Benzaldehyde bis(phenylmethyl)hydrazone;Benzaldehyde dibenzyl hydrazone
• CAS NO: 21136-32-3
• Molecular Formula: C₂₁H₂₀N₂
• Molecular Weight: 300.3969
• Mol File: 21136-32-3.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 490°Cat760mmHg
• Flash Point: 250.1°C
• Appearance: /
• Density: 0.99g/cm³
• Vapor Pressure: 9.52E-10mmHg at 25°C
• Refractive Index: 1.57
• CAS DataBase Reference: 1,1-Dibenzyl-2-benzylidenehydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-Dibenzyl-2-benzylidenehydrazine(21136-32-3)
• EPA Substance Registry System: 1,1-Dibenzyl-2-benzylidenehydrazine(21136-32-3)

Safety Data

• Hazardous Substances Data: 21136-32-3(Hazardous Substances Data)

Usage

Chemical compound

Yes

Use

Key intermediate in the synthesis of organic compounds

Potential biological activity

Yes

Studied for

Anti-cancer agent

Ability

Inhibits the growth of cancer cells

Investigated for

Treatment of neurological disorders

Research suggestion

Neuroprotective properties

Unique structure

Yes

Subject of study

Pharmaceutical and chemical industries

InChI:InChI=1/C21H20N2/c1-4-10-19(11-5-1)16-22-23(17-20-12-6-2-7-13-20)18-21-14-8-3-9-15-21/h1-16H,17-18H2

Upstream product

• 5336-53-8 dibenzylnitrosamine 
• 17352-65-7 tribenzyl-hydrazine; hydrochloride 
• 100-52-7 benzaldehyde 
• 5802-60-8 N,N-dibenzylhydrazine 
• 64-17-5 ethanol 
• 64-19-7 acetic acid 
• 103-49-1 dibenzylamine 
• 104-88-1 4-chlorobenzaldehyde 
• 7626-68-8 N,N'-dibenzylhydrazine 
• 26254-04-6 N,N'-dibenzyl-hydrazine; hydrochloride 
• 1194-66-7 2,6-dichloronitrosobenzene 

Downstream Products

• 65111-78-6 tribenzyl-hydrazine 
• 5416-62-6 tetrabenzyl-hydrazine 
• 36750-88-6 1-phenyl-3,3,3-trifluoro-1,2-propanedione 
• 20698-90-2 (R)-3,3,3-Trifluoro-2-hydroxy-2-phenyl-propionic acid methyl ester 
• 20445-31-2 R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid 

Relevant articles and documents

Oxidation of 1,1-Disubstituted Hydrazines to Tetrazenes with Benzeneseleninic Acid

The oxidation of 1,1-disubstituted hydrazines with benzeneseleninic acid in methanol affords the corresponding tetrazenes in high yield.

Visible-light-enabled C(sp2)-H difluoroalkylation of aldehyde-derived hydrazones under metal-free conditions

A Eosin Y-catalyzed C(sp2)-H difluoromethylation of aldehyde-derived hydrazones between difluoroalkyl bromides and aldehyde-derived hydrazones is reported. This reaction has a wide range of substrates and occurs under metal-free condition. A me

Asymmetric 1,2-Perfluoroalkyl Migration: Easy Access to Enantioenriched α-Hydroxy-α-perfluoroalkyl Esters

This study has led to the development of a novel, highly efficient, 1,2-perfluoro-alkyl/-aryl migration process in reactions of hydrate of 1-perfluoro-alkyl/-aryl-1,2-diketones with alcohols, which are promoted by a Zn(II)/bisoxazoline and form α-perfluoro-alkyl/-aryl-substituted α-hydroxy esters. With (-)-8-phenylmenthol as the alcohol, the corresponding menthol esters are generated in high yields with excellent levels of diastereoselectivity. The mechanistic studies show that the benzilic ester-type rearrangement reaction takes place via an unusual 1,2-migration of electron-deficient trifluoromethyl group rather than the phenyl group. The overall process serves as a novel, efficient, and simple approach for the synthesis of highly enantioenriched, biologically relevant α-hydroxy-α-perfluoroalkyl carboxylic acid derivatives.