211438-72-1

Basic information

• Product Name: N-Hexadecyl-N-methyl-2-(tetrahydro-pyran-2-yloxymethyl)-benzamide
• Synonyms: N-Hexadecyl-N-methyl-2-(tetrahydro-pyran-2-yloxymethyl)-benzamide
• CAS NO: 211438-72-1
• Molecular Weight: 473.74
• Mol File: 211438-72-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-Hexadecyl-N-methyl-2-(tetrahydro-pyran-2-yloxymethyl)-benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Hexadecyl-N-methyl-2-(tetrahydro-pyran-2-yloxymethyl)-benzamide(211438-72-1)
• EPA Substance Registry System: N-Hexadecyl-N-methyl-2-(tetrahydro-pyran-2-yloxymethyl)-benzamide(211438-72-1)

Safety Data

• Hazardous Substances Data: 211438-72-1(Hazardous Substances Data)

Upstream product

• 20779-14-0 methanesulfonic acid hexadecyl ester 
• 211438-67-4 N-Methyl-2-(tetrahydro-pyran-2-yloxymethyl)-benzamide 
• 211438-69-6 N-Hexadecyl-2-(tetrahydro-pyran-2-yloxymethyl)-benzamide 
• 74-88-4 methyl iodide 
• 550-44-7 N-methylphthalimide 
• 61020-43-7 N-hexadecyl-phthalimide 
• 211438-65-2 N-Hexadecyl-2-hydroxymethyl-benzamide 
• 39976-03-9 2-(hydroxymethyl)-N-methylbenzamide 
• 136918-14-4 phthalimide 

Downstream Products

• 13417-08-8 N-methyl-1-hexadecanamine 

Relevant articles and documents

A new strategy for the preparation of secondary amines via o- (tetrahydropyranyloxymethyl)-benzamides

The new synthesis strategy for the preparation of secondary amines starts from N-alkyl-phthalimides which are reduced to the corresponding o- hydroxymethyl-N-alkyl-benzamides. After protection of the hydroxy group as tetrahydropyranyl ether the N-alkyl-benzamides are alkylated to o- (tetrahydropyranyloxymethyl)-N,N-dialkyl-benzamides. The deprotection of the hydroxy group and the release of the secondary amines can be achieved in execellent yields in one reaction step using aqueous acetic acid.