211438-74-3Relevant articles and documents
A new strategy for the preparation of secondary amines via o- (tetrahydropyranyloxymethyl)-benzamides
Fichert, Thomas,Massing, Ulrich
, p. 5017 - 5018 (2007/10/03)
The new synthesis strategy for the preparation of secondary amines starts from N-alkyl-phthalimides which are reduced to the corresponding o- hydroxymethyl-N-alkyl-benzamides. After protection of the hydroxy group as tetrahydropyranyl ether the N-alkyl-benzamides are alkylated to o- (tetrahydropyranyloxymethyl)-N,N-dialkyl-benzamides. The deprotection of the hydroxy group and the release of the secondary amines can be achieved in execellent yields in one reaction step using aqueous acetic acid.