21152-87-4Relevant articles and documents
Synthesis of C-C bonded dimeric steroids by olefin metathesis
Edelsztein, Valeria C.,Di Chenna, Pablo H.,Burton, Gerardo
, p. 3615 - 3623 (2009)
Five new C-C bonded steroidal homodimers derived from deoxycholic acid, pregnenolone, and progesterone were synthesized by an olefin metathesis reaction assisted by microwave heating. Microwave improved the yield and accelerated the reaction allowing the use of less catalyst with good results (2.5 mol %). Due to the bulky nature of the steroidal skeleton the more favorable E-dimers were formed as the sole or major products depending on the linker length.
Amino steroids as antimalarial agents
Sharma, Upasana,Srivastava, Kumkum,Puri, Sunil K.,Singh, Chandan
, p. 326 - 334 (2008/12/22)
Using easily accessible deoxycholic acid as the starting material, amino compounds 8a-e and 9a-c were prepared and screened against P. falciparum in vitro. Amino steroid 8d was the most active of the series with a minimum inhibiting concentration (MIC) of
Degradation of bile acid side chain with lead tetraacetate.
Vaidya,Dixit,Rao
, p. 5173 - 5174 (2007/10/17)
-