212002-71-6

Basic information

• Product Name: ethyl 2-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoyl]-4-methyl-5-oxo-2,5-dihydroisoxazole-3-carboxylate
• CAS NO: 212002-71-6
• Molecular Weight: 372.334
• Mol File: 212002-71-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl 2-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoyl]-4-methyl-5-oxo-2,5-dihydroisoxazole-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoyl]-4-methyl-5-oxo-2,5-dihydroisoxazole-3-carboxylate(212002-71-6)
• EPA Substance Registry System: ethyl 2-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoyl]-4-methyl-5-oxo-2,5-dihydroisoxazole-3-carboxylate(212002-71-6)

Safety Data

• Hazardous Substances Data: 212002-71-6(Hazardous Substances Data)

Upstream product

• 84280-59-1 ethyl 4-methyl-5-oxo-2,5-dihydro-1,2-oxazole-3-carboxylate 
• 4192-28-3 Phth-L-Ala-OH 

Downstream Products

• 404935-22-4 2-((S)-1-Amino-ethyl)-5-methyl-oxazole-4-carboxylic acid 

Relevant articles and documents

The synthesis of some chiral 2-aminoalkyloxazole-4-carboxylates from isoxazol-5(2H)-ones

Ethyl 4-methyl-5-oxo-2,5-dihydroisoxazole-3-carboxylate can be N-acylated by a number of natural and synthetic phthalimidylamino acids in the presence of carbodiimides. The N-acyiated products form the corresponding oxazoles smoothly when irradiated at 300 nm in acetone. Removal of the phthalimido protecting group then gives 2-aminoalkyloxazole-4-carboxylate esters in good overall yields, and without significant racemization at any step.