21203-88-3 Usage
General Description
Diethyl 4-(4,5-dimethoxy-2-nitrophenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate, also known as Verapamil, is a chemical compound used in the treatment of high blood pressure, angina, and certain heart rhythm disorders. It belongs to the class of drugs known as calcium channel blockers, which work by relaxing the muscles of the blood vessels and heart, allowing for easier blood flow and reducing the workload on the heart. Verapamil is also used off-label for the treatment of migraines and cluster headaches, and in the prevention of certain types of cardiac arrhythmias. It is available in various forms, including tablets, extended-release capsules, and injections for intravenous administration. Like all medications, Verapamil should be used under the supervision of a healthcare professional, as it may have potential side effects and interactions with other drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 21203-88-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,2,0 and 3 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 21203-88:
(7*2)+(6*1)+(5*2)+(4*0)+(3*3)+(2*8)+(1*8)=63
63 % 10 = 3
So 21203-88-3 is a valid CAS Registry Number.
InChI:InChI=1/C21H26N2O8/c1-7-30-20(24)17-11(3)22-12(4)18(21(25)31-8-2)19(17)13-9-15(28-5)16(29-6)10-14(13)23(26)27/h9-10,19,22H,7-8H2,1-6H3
21203-88-3Relevant articles and documents
A Novel 4-(4,5-dimethoxy-2-nitrophenyl)-2,6-dimethyl-3,5-dicarbethoxy-1,4-dihydropyridine (C21H26N2O8): Microwave-irradiated hantzsch ester synthesis, characterization and molecular crystal
Maru, Minaxi S.,Shah, Manish K.
, p. 217 - 225 (2015)
The novel 4-(4,5-dimethoxy-2-nitrophenyl)-2,6-dimethyl-3,5-dicarbethoxy-1,4-dihydropyridine was synthesized through multicomponent one pot Hantzsch ester synthesis using 4,5-dimethoxy-2-nitrobenzaldehyde, ethyl 3-oxobutanoate, and ammonium carbonate under microwave irradiation and subsequently characterized by several spectroscopic techniques, i.e., ESI mass, IR, 1H, and 13C NMR along with single crystal X-ray diffraction method. The single crystal of 4-(4,5-dimethoxy-2-nitrophenyl)-2,6-dimethyl-3,5-dicarbethoxy-1,4-dihydropyridine (C21H26N2O8) was developed in 0.35 × 0.30 × 0.25 mm dimension in methanol. The crystal structure parades only intermolecular hydrogen bonding of the N(2)-H(2A). O(2) type and the boat conformation of the dihydropyridine ring.
