212060-91-8

Basic information

• Product Name: [(2S,3R,4R,5R)-4-(2,4-Dichloro-benzyloxy)-5-(2,4-dichloro-benzyloxymethyl)-2-methoxy-tetrahydro-furan-3-yloxy]-acetic acid ethyl ester
• Synonyms: [(2S,3R,4R,5R)-4-(2,4-Dichloro-benzyloxy)-5-(2,4-dichloro-benzyloxymethyl)-2-methoxy-tetrahydro-furan-3-yloxy]-acetic acid ethyl ester
• CAS NO: 212060-91-8
• Molecular Weight: 568.278
• Mol File: 212060-91-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [(2S,3R,4R,5R)-4-(2,4-Dichloro-benzyloxy)-5-(2,4-dichloro-benzyloxymethyl)-2-methoxy-tetrahydro-furan-3-yloxy]-acetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [(2S,3R,4R,5R)-4-(2,4-Dichloro-benzyloxy)-5-(2,4-dichloro-benzyloxymethyl)-2-methoxy-tetrahydro-furan-3-yloxy]-acetic acid ethyl ester(212060-91-8)
• EPA Substance Registry System: [(2S,3R,4R,5R)-4-(2,4-Dichloro-benzyloxy)-5-(2,4-dichloro-benzyloxymethyl)-2-methoxy-tetrahydro-furan-3-yloxy]-acetic acid ethyl ester(212060-91-8)

Safety Data

• Hazardous Substances Data: 212060-91-8(Hazardous Substances Data)

Upstream product

• 105-36-2 ethyl bromoacetate 
• 168427-35-8 (3R,4S,5R)-4-((2,4-dichlorobenzyl)oxy)-5-(((2,4-dichlorobenzyl)oxy)methyl)-2-methoxytetrahydrofuran-3-ol 

Downstream Products

• 212060-93-0 [(2R,3R,4R,5R)-4-(2,4-Dichloro-benzyloxy)-5-(2,4-dichloro-benzyloxymethyl)-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-acetic acid ethyl ester 
• 173366-51-3 1-[2'-O-(2-Hydroxyethyl)-3',5'-bis-O-(2,4-dichlorobenzyl)-β-D-ribofuranosyl]thymine 
• 212060-99-6 2-{2-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-ethoxy}-isoindole-1,3-dione 
• 212060-96-3 2-{2-[(2R,3R,4R,5R)-4-(2,4-Dichloro-benzyloxy)-5-(2,4-dichloro-benzyloxymethyl)-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-ethoxy}-isoindole-1,3-dione 

Relevant articles and documents

Synthesis, hybridization, and nuclease resistance properties of 2'-O- aminooxyethyl (2'-O-AOE) modified oligonucleotides

The novel RNA mimic 2'-O-AOE has been incorporated into antisense oligonucleotides. This 2'-O-modification significantly enhances hybridization against target RNA, and furthermore, exhibits specificity for RNA over DNA. The nuclease resistance (SVPD) of 2'-O-AOE modified phosphodiester oligonucleotides is significantly higher than the unmodified DNA and comparable to the 2'-O-MOE oligonucleotides.