212127-83-8 Usage
Description
TERT-BUTYL 3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXYLATE, also known as 1-Boc-2,5-Dihydro-1H-pyrrole-3-boronic acid, pinacol ester, is a chemical compound with a complex structure. It is characterized by its boronic acid and pinacol ester functional groups, which contribute to its unique chemical properties and reactivity.
Uses
Used in Pharmaceutical Industry:
TERT-BUTYL 3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXYLATE is used as a key intermediate in the synthesis of a series of kinase inhibitors. Kinase inhibitors are important in the development of targeted therapies for various diseases, including cancer and autoimmune disorders. The compound's unique structure allows for the formation of specific interactions with kinase enzymes, leading to their inhibition and potentially providing therapeutic benefits.
In the synthesis of kinase inhibitors, TERT-BUTYL 3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXYLATE serves as a valuable building block due to its reactivity and the ability to form stable bonds with other molecules. This makes it a crucial component in the development of novel and effective therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 212127-83-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,2,1,2 and 7 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 212127-83:
(8*2)+(7*1)+(6*2)+(5*1)+(4*2)+(3*7)+(2*8)+(1*3)=88
88 % 10 = 8
So 212127-83-8 is a valid CAS Registry Number.
212127-83-8Relevant articles and documents
Multigram Synthesis of Heterabicyclo[n.1.0]alkan-1-yl Trifluoroborates
Kleban, Ihor,Krokhmaliuk, Yevhen,Reut, Sofiia,Shuvakin, Serhii,Pendyukh, Vyacheslav V.,Khyzhan, Oleksandr I.,Yarmoliuk, Dmytro S.,Tymtsunik, Andriy V.,Rassukana, Yuliya V.,Grygorenko, Oleksandr O.
, p. 6551 - 6560 (2020/09/17)
An approach to the synthesis of oxa- and azabicyclo[n.1.0]alkan-1-yl trifluoroborates on a multigram scale was developed. Two synthetic strategies were evaluated: the first based on the lithiation–borylation of the corresponding 2-bromoallyl derivatives, and the other relying on regioselective hydroboration of the appropriate hetera-substituted enynes. The second method appeared to be more efficient in terms of scalability and substrate scope. Further steps included ring closing-metathesis, mild palladium-catalyzed cyclopropanation with diazomethane, and reaction with KHF2 and furnished the title compounds in up to 50 g scale in a single run (10–41 % overall yield, 4–5 steps).
INDOLO HEPTAMYL OXIME ANALOGUE AS PARP INHIBITOR
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, (2021/12/15)
Disclosed is a type of indolo heptamyl oxime compounds as a PARP inhibitor. Specifically disclosed are a compound as represented by formula (II) and a pharmaceutically acceptable salt thereof.
BICYCLIC HETEROARENES AND METHODS OF THEIR USE
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, (2021/12/30)
Disclosed are compounds useful in the treatment of neurological disorders. The compounds described herein, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological diseases.
