21217-67-4Relevant articles and documents
Antitumor activity of ribonuclease multimers created by site-specific covalent tethering
Rutkoski, Thomas J.,Kink, John A.,Strong, Laura E.,Schilling, Christine I.,Raines, Ronald T.
, p. 1691 - 1702 (2010)
Site-specific cross-linking can generate homogeneous multimeric proteins of defined valency. Pancreatic-type ribonucleases are an especially attractive target, as their natural dimers can enter mammalian cells, evade the cytosolic ribonuclease inhibitor (