212322-17-3

Basic information

• Product Name: Benzoic acid, 3-amino-4-formyl-, methyl ester
• CAS NO: 212322-17-3
• Molecular Formula: C9H9NO3
• Molecular Weight: 179.175
• Mol File: 212322-17-3.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 3-amino-4-formyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 3-amino-4-formyl-, methyl ester(212322-17-3)
• EPA Substance Registry System: Benzoic acid, 3-amino-4-formyl-, methyl ester(212322-17-3)

Safety Data

• Hazardous Substances Data: 212322-17-3(Hazardous Substances Data)

Upstream product

• 7439-89-6 iron 
• 153813-69-5 methyl 4-formyl-3-nitrobenzoate 
• 841297-68-5 3-amino-4-dimethoxymethyl-benzoic acid methyl ester 

Downstream Products

• 841297-69-6 2-phenylquinoline-7-carboxylic acid 
• 953039-79-7 methyl 2-chloroquinazoline-7-carboxylate 
• 1315578-08-5 methyl 2-phenylquinazoline-7-carboxylate 
• 1309581-11-0 methyl 4-formyl-3-(2,2,2-trifluoroacetamido)benzoate 
• 1254343-16-2 (S)-methyl 7-phenyl-5,6,7,8-tetrahydroacridine-3-carboxylate 
• 953039-78-6 methyl 2-hydroxy-quinazoline-7-carboxylate 

Relevant articles and documents

The discovery of potent small molecule activators of human STING

The adaptor protein STING plays a major role in innate immune sensing of cytosolic nucleic acids, by triggering a robust interferon response. Despite the importance of this protein as a potential therapeutic target for serious unmet medical conditions inc

SMALL MOLECULE STING ANTAGONISTS

The present invention relates to compounds of formula (I). The compounds maybe used to antagonise the Stimulator of Interferon Genes (STING) protein and may thereby treat liver fibrosis, fatty liver disease, non-alcoholic steatohepatitis (NASH), pulmonary fibrosis, lupus, sepsis, rheumatoid arthritis (RA), type I diabetes, STING- associated vasculopathy with onset in infancy (SAVI), Aicardi-Goutieres syndrome (AGS), familial chilblain lupus (FCL), systemic lupus erythematosus (SLE), retinal vasculopathy, neuroinflammation, systemic inflammatory response syndrome, pancreatitis, cardiovascular disease, renal fibrosis, stroke and age-related macular degeneration (AMD).

Gold(I)-catalyzed unprecedented rearrangement reaction between 2-aminobenzaldehydes with propargyl amines: An expedient route to 3-aminoquinolines

Access to aminoquinolines: A gold(I)-catalyzed unprecedented rearrangement reaction between 2-aminobenzaldehydes with propargyl amine was studied. The study provided, for the first time, direct access to 3-aminoquinolines in one step starting from readily available starting materials (see scheme). Elegantly designed experiments were employed to unravel the mechanism of this unprecedented rearrangement, which are corroborated by DFT calculations.