212332-40-6

Basic information

• Product Name: 3-bromo-5-isopropoxypyridine
• Synonyms: 3-bromo-5-isopropoxypyridine;3-Bromo-5-(1-methylethoxy)pyridine;3-Bromo-5-[(1-methylethyl)oxy]pyridine;5-Bromo-3-isopropoxypyridine;5-Isopropoxy-3-bromopyridine
• CAS NO: 212332-40-6
• Molecular Formula: C₈H₁₀BrNO
• Molecular Weight: 216.0751
• Mol File: 212332-40-6.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 241℃
• Flash Point: 100℃
• Appearance: /
• Density: 1.383
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-bromo-5-isopropoxypyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-bromo-5-isopropoxypyridine(212332-40-6)
• EPA Substance Registry System: 3-bromo-5-isopropoxypyridine(212332-40-6)

Safety Data

• Hazardous Substances Data: 212332-40-6(Hazardous Substances Data)

Usage

General Description

3-Bromo-5-isopropoxypyridine is a chemical compound belonging to the organic class of compounds known as pyridines and derivatives. Its molecular formula is C8H10BrNO and it has a molecular weight of 224.07 g/mol. The presence of bromine, isopropoxy group, and pyridine in the structure contributes to the chemical behavior and reactivity of this compound. In terms of physical properties, information regarding its appearance, color, taste, and boiling or melting points would be greatly variable and dependent on conditions such as purity and concentration. Specific applications and uses of this substance have not been extensively documented, but like other pyridine derivatives, they are generally used in the preparation of various pharmaceuticals, agrochemicals, and dyestuffs.

Upstream product

• 74115-13-2 5-bromopyridine-3-ol 
• 6804-20-2 O-isopropyl-N,N'-dicyclohexyl-isourea 
• 75-30-9 2-iodo-propane 
• 75-26-3 isopropyl bromide 
• 67-63-0 isopropyl alcohol 

Downstream Products

• 850991-41-2 (5-isopropoxypyridin-3-yl)boronic acid 
• 1171892-42-4 3-[(1-methylethyl)oxy]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 
• 130722-95-1 3-(benzyloxy)-5-bromopyridine 
• 28232-63-5 5-bromo-3-phenoxypyridine 
• 1383133-85-4 3-bromo-5-(2-methoxyphenoxy)pyridine 
• 374935-00-9 3-bromo-5-(3-methoxyphenoxy)pyridine 
• 374934-98-2 3-bromo-5-(4-methoxyphenoxy)pyridine 
• 28232-64-6 3-bromo-5-(2-chlorophenoxy)pyridine 
• 28232-65-7 3-bromo-5-(3-chlorophenoxy)pyridine 
• 28232-66-8 3-bromo-5-(4-chlorophenoxy)pyridine 
• 374935-03-2 3-bromo-5-(4-fluorophenoxy)pyridine 

Relevant articles and documents

AZAINDOLE CARBOXAMIDE COMPOUNDS FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS

Provided herein are compounds of Formula (I) and Formula (II): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of tuberculosis.

Fine-tuning the selectivity of aldosterone synthase inhibitors: Structure-activity and structure-selectivity insights from studies of heteroaryl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1- ij ]quinolin-4-one derivatives

Pyridine substituted 3,4-dihydro-1H-quinolin-2-ones (e.g., 1-3) constitute a class of highly potent and selective inhibitors of aldosterone synthase (CYP11B2), a promising target for the treatment of hyperaldosteronism, congestive heart failure, and myocardial fibrosis. Among these, ethyl-substituted 3 possesses high selectivity against CYP1A2. Rigidification of 3 by incorporation of the ethyl group into a 5- or 6-membered ring affords compounds with a pyrroloquinolinone or pyridoquinolinone molecular scaffold (e.g., 4 and 5). It was found that these molecules are even more potent and selective CYP11B2 inhibitors than their corresponding open-chain analogues. Moreover, pyrroloquinolinone 4 exhibits no inhibition of the six most important hepatic CYP enzymes as well as a bioavailability in the range of the marketed drug fadrozole. The SAR studies disclose that subtle changes in the heterocyclic moiety are responsible for either a strong or a weak inhibition of the highly homologous 11-hydroxylase (CYP11B1). These results are not only important for fine-tuning the selectivity of CYP11B2 inhibitors but also for the development of selective CYP11B1 inhibitors that are of interest for the treatment of Cushing's syndrome and metabolic syndrome.

PYRIMIDINE DERIVATIVES USED AS ITK INHIBITORS

The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular ltk activity.