212578-38-6

Basic information

• Product Name: 4-methyl-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid
• Synonyms: 4-methyl-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid;3,4-Dihydro-4-methyl-2H-1,4-benzoxazine-2-carboxylic acid 97%;2-Carboxy-3,4-dihydro-4-methyl-2H-1,4-benzoxazine, 2-Carboxy-3,4-dihydro-4-methyl-2H-benzo[b][1,4]oxazine;3,4-Dihydro-4-methyl-2H-1,4-benzoxazine-2-carboxylicacid97%;4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxylic acid
• CAS NO: 212578-38-6
• Molecular Formula: C10H11NO3
• Molecular Weight: 193.2
• Mol File: 212578-38-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 376.346°C at 760 mmHg
• Flash Point: 181.408°C
• Appearance: /
• Density: 1.283g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.575
• CAS DataBase Reference: 4-methyl-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid(212578-38-6)
• EPA Substance Registry System: 4-methyl-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid(212578-38-6)

Safety Data

• Hazardous Substances Data: 212578-38-6(Hazardous Substances Data)

Usage

General Description

The chemical 4-methyl-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid is a heterocyclic compound with a benzoxazine ring structure. It contains a carboxylic acid functional group and a methyl group attached to the benzoxazine ring. This chemical has potential applications in organic synthesis, pharmaceuticals, and materials science. It may be used as a building block for the synthesis of various organic compounds, and research into its properties and potential uses is ongoing.

InChI:InChI=1/C10H11NO3/c1-11-6-9(10(12)13)14-8-5-3-2-4-7(8)11/h2-5,9H,6H2,1H3,(H,12,13)

Upstream product

• 54442-28-3 ethyl 4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxylate 
• 95-55-6 2-amino-phenol 
• 22244-22-0 ethyl 3,4-dihydro-2H-benzo [b][1,4]oxazine-2-carboxylate 
• 88-75-5 2-hydroxynitrobenzene 

Downstream Products

• 212578-41-1 2-{N-[2-(3,4-dimethoxyphenyl)ethyl]carbamoyl}-4-methyl-3,4-dihydro-2H-1,4-benzoxazine 
• 1027148-11-3 [4-(4-Fluoro-phenyl)-piperazin-1-yl]-(4-methyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-methanone 

Relevant articles and documents

5-AMINO-4-CARBAMOYL-PYRAZOLE COMPOUNDS AS SELECTIVE AND IRREVERSIBLE T790M OVER WT-EGFR KINASE INHIBITORS AND USE THEREOF????

Disclosed are compounds of Formula (I), pharmaceutical compositions comprising the same, processes for the preparation thereof, and the use thereof.

Synthesis and biological evaluation of new 2-(4,5-dihydro-1H-imidazol-2-yl)-3,4-dihydro-2H-1,4-benzoxazine derivatives

2-(4,5-Dihydro-1H-imidazol-2-yl)-3,4-dihydro-2H-1,4-benzoxazine derivatives and tricyclic analogues with a fused additional ring on the nitrogen atom of the benzoxazine moiety have been prepared and evaluated for their cardiovascular effects as potential antihypertensive agents. The imidazoline ring was generated by reaction of the corresponding ethyl ester with ethylenediamine. Affinities for imidazoline binding sites (IBS) I1 and I2 and α1 and α2 adrenergic receptors were evaluated as well as the effects on mean arterial blood pressure (MAP) and heart rate (HR) of spontaneously hypertensive rats. With few exceptions the most active compounds on MAP were those with high affinities for IBS and α2 receptor. Among these, compound 4h was the most interesting and is now, together with its enantiomers, under complementary pharmacological evaluation.