21259-42-7

Basic information

• Product Name: 2-Oxo-2H-1-benzopyran-3-carboxylic acid methyl ester
• Synonyms: 2-Oxo-2H-1-benzopyran-3-carboxylic acid methyl ester;methyl 2-oxochromene-3-carboxylate
• CAS NO: 21259-42-7
• Molecular Formula: C₁₁H₈O₄
• Molecular Weight: 204.1788
• Mol File: 21259-42-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 368.9°Cat760mmHg
• Flash Point: 192.9°C
• Appearance: /
• Density: 1.337g/cm³
• Vapor Pressure: 1.23E-05mmHg at 25°C
• Refractive Index: 1.578
• CAS DataBase Reference: 2-Oxo-2H-1-benzopyran-3-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Oxo-2H-1-benzopyran-3-carboxylic acid methyl ester(21259-42-7)
• EPA Substance Registry System: 2-Oxo-2H-1-benzopyran-3-carboxylic acid methyl ester(21259-42-7)

Safety Data

• Hazardous Substances Data: 21259-42-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H8O4/c1-14-10(12)8-6-7-4-2-3-5-9(7)15-11(8)13/h2-6H,1H3

Upstream product

• 1173178-79-4 dimethyl 2-(2-(benzyloxy)benzylidene)malonate 
• 123-08-0 4-hydroxy-benzaldehyde 
• 108-59-8 malonic acid dimethyl ester 

Downstream Products

• 872279-48-6 1-benzoyl-2-oxo-1,7b-dihydro-2H-cyclopropa[c]chromene-1a-carboxylic acid methyl ester 
• 126814-17-3 methyl 3-(2-hydroxyphenyl)-2-methoxycarbonyl-4-nitrobutyrate 
• 126814-18-4 ethyl 2-ethoxycarbonyl-3-(2-hydroxyphenyl)-4-nitrobutyrate 
• 126814-19-5 ethyl 3-(2-hydroxyphenyl)-2-methoxycarbonyl-4-nitrobutyrate 
• 153357-13-2 2-Oxo-2H-chromene-3-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 134594-03-9 9-<(tert-butyldimethylsilyl)oxy>-6a-(methoxycarbonyl)-7-phenyl-6a,7,10,10a-tetrahydro-6H-dibenzopyran-6-one 
• 153357-14-3 3-(8-phenylmenthyloxycarbonyl)coumarin 
• 132755-45-4 methyl ester of 2,2-dichloro-3-(2-hydroxyphenyl) cyclopropanecarboxylic acid 
• 132755-41-0 methyl ester of 4-trichloromethyl-2-oxochroman-3-carboxylic acid 
• 531-81-7 2-oxo-2H-chromene-3-carboxylic acid 
• 3757-06-0 coumarin 3-carboxylic acid chloride 
• 1846-76-0 ethyl coumarin-3-carboxylate 

Relevant articles and documents

Indium(III)-catalyzed knoevenagel condensation of aldehydes and activated methylenes using acetic anhydride as a promoter

The combination of a catalytic amount of InCl3 and acetic anhydride remarkably promotes the Knoevenagel condensation of a variety of aldehydes and activated methylene compounds. This catalytic system accommodates aromatic aldehydes containing a variety of electron-donating and -withdrawing groups, heteroaromatic aldehydes, conjugate aldehydes, and aliphatic aldehydes. Central to successfully driving the condensation series is the formation of a geminal diacetate intermediate, which was generated in situ from an aldehyde and an acid anhydride with the assistance of an indium catalyst.