21262-08-8

Basic information

• Product Name: PropanaMide, N-(4-broMophenyl)-2-chloro-
• Synonyms: PropanaMide, N-(4-broMophenyl)-2-chloro-;N-(4-bromophenyl)-2-chloro-propionamide;T0516-8824
• CAS NO: 21262-08-8
• Molecular Formula: C₉H₉BrClNO
• Molecular Weight: 262.53086
• Mol File: 21262-08-8.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: PropanaMide, N-(4-broMophenyl)-2-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: PropanaMide, N-(4-broMophenyl)-2-chloro-(21262-08-8)
• EPA Substance Registry System: PropanaMide, N-(4-broMophenyl)-2-chloro-(21262-08-8)

Safety Data

• Hazardous Substances Data: 21262-08-8(Hazardous Substances Data)

Upstream product

• 21262-52-2 2-chloro-N-phenylpropanamide 
• 19103-79-8 2-chloro-propionyl isothiocyanate 
• 106-40-1 4-bromo-aniline 
• 7623-09-8 2-chloropropionyl chloride 
• 103-88-8 4-bromoacetanilide 

Downstream Products

• 868771-26-0 N-(4-bromo-2-nitro-phenyl)-2-chloro-propionamide 
• 24463-25-0 6-bromo-3-methyl-3,4-dihydro-1H-quinoxalin-2-one 
• 868771-37-3 N-(2-amino-4-bromo-phenyl)-2-chloro-propionamide 

Relevant articles and documents

Optimization of bifunctional piperidinamide derivatives as σ1R Antagonists/MOR agonists for treating neuropathic pain

Here, we describe the optimization, synthesis, and associated pharmacological analgesic activities of a new series of bifunctional piperidinamide derivatives as sigma-1 receptor (σ1R) antagonists and mu opioid receptor (MOR) agonists. The new compounds were evaluated in vitro in σ1R and MOR binding assays. The most promising compound 114 (also called HKC-126), showed superior affinities for σ1R and MOR and good selectivity to additional receptors related to pain. Compound 114 showed powerful dose-dependent analgesic effects in the acetic acid writhing test, formalin test, hot plate test, and chronic constriction injury (CCI) neuropathic pain model. In contrast to an equianalgesic dose of fentanyl, compound 114 produced fewer opioid-like side effects, such as reward liability, respiratory depression, physical dependence, and sedation. Lastly, the pharmacokinetic properties of this drug were also acceptable, and these results suggest that compound 114, as a mixed σ1R/MOR ligand, has potential for treating neuropathic pain.

Synthesis of substituted 1,3-dimethyl-1H-quinoxalin-2-ones from aniline derivatives

Substituted 1,3-dimethyl-1H-quinoxalin-2-ones (7) have been synthesized through the procedures of acylation, nitration, reduction, intramolecular alkylation, oxidation, and N-methylation starting from 3,4-disubstituted aniline.

AlCl3-Catalysed trans N-acylation of Acetanilides with α-Chloropropionyl Chloride

trans N-acylation of acetanilides with α-chloropropionyl chloride catalysed by AlCl3 has been shown to occur efficiently, affording 2-chloro-N-phenylpropanamides in preparative yields.